Universität zu Köln

Collins, Graham P., Rueda, Antonio, Salles, Gilles, von Tresckow, Bastian and Zaja, Francesco ORCID: 0000-0003-3995-8817 (2018). Management of Hodgkin lymphoma in the era of brentuximab vedotin: real-world data from five European countries. Leuk. Lymphoma, 59 (9). S. 2113 - 2121. ABINGDON: TAYLOR & FRANCIS LTD. ISSN 1029-2403

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Abstract

We examined real-world data on management of relapsed/refractory Hodgkin lymphoma (R/R HL) in five European countries and the consistency of these data with guideline recommendations. Retrospective clinical and epidemiologic data for 509 patients with R/R HL treated between January 2014 and March 2015 were collected at centers in France, Germany, Italy, Spain, and the United Kingdom. Mean age was 46.3 years; 73.3% were receiving second-line therapy for a first relapse during the reporting period. Most patients received ABVD as front-line chemotherapy, except in Germany where escalated BEACOPP was used more often. The proportion of patients receiving stem cell transplantation (SCT) was 44%; 85% of transplants occurred at first relapse. Brentuximab vedotin (BV) was usually administered after autologous SCT, and was initiated for 65% of patients following SCT failure. Our findings suggest that R/R HL management across these countries is broadly consistent with guideline recommendations and that BV is well-integrated into treatment pathways.

Item Type:	Journal Article
Creators:	Creators Email ORCID ORCID Put Code Collins, Graham P. UNSPECIFIED UNSPECIFIED UNSPECIFIED Rueda, Antonio UNSPECIFIED UNSPECIFIED UNSPECIFIED Salles, Gilles UNSPECIFIED UNSPECIFIED UNSPECIFIED von Tresckow, Bastian UNSPECIFIED UNSPECIFIED UNSPECIFIED Zaja, Francesco UNSPECIFIED orcid.org/0000-0003-3995-8817 UNSPECIFIED
URN:	urn:nbn:de:hbz:38-200750
DOI:	10.1080/10428194.2017.1421762
Journal or Publication Title:	Leuk. Lymphoma
Volume:	59
Number:	9
Page Range:	S. 2113 - 2121
Date:	2018
Publisher:	TAYLOR & FRANCIS LTD
Place of Publication:	ABINGDON
ISSN:	1029-2403
Language:	English
Faculty:	Unspecified
Divisions:	Unspecified
Subjects:	no entry
Uncontrolled Keywords:	Keywords Language STEM-CELL TRANSPLANTATION; MULTICENTER ANALYSIS; PROGNOSTIC-FACTORS; CLINICAL-PRACTICE; FOLLOW-UP; EXPERIENCE; TRIAL; DIAGNOSIS; THERAPY; BLOCKADE Multiple languages Oncology; Hematology Multiple languages
Refereed:	Yes
URI:	http://kups.ub.uni-koeln.de/id/eprint/20075