Steigerwald, Frank ORCID: 0000-0002-8305-1684, Timmermann, Lars, Kuehn, Andrea, Schnitzler, Alfons ORCID: 0000-0002-6414-7939, Reich, Martin M., Kirsch, Anna Dalal, Barbe, Michael Thomas, Visser-Vandewalle, Veerle, Huebl, Julius, van Riesen, Christoph, Groiss, Stefan Jun, Moldovan, Alexia-Sabine, Lin, Sherry, Carcieri, Stephen, Manola, Ljubomir and Volkmann, Jens (2018). Pulse Duration Settings in Subthalamic Stimulation for Parkinson's Disease. Mov. Disord., 33 (1). S. 165 - 170. HOBOKEN: WILEY. ISSN 1531-8257

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Abstract

Background: Stimulation parameters in deep brain stimulation (DBS) of the subthalamic nucleus for Parkinson's disease (PD) are rarely tested in double-blind conditions. Evidence-based recommendations on optimal stimulator settings are needed. Results from the CUSTOM-DBS study are reported, comparing 2 pulse durations. Methods: A total of 15 patients were programmed using a pulse width of 30 mu s (test) or 60 mu s (control). Efficacy and side-effect thresholds and unified PD rating scale (UPDRS) III were measured in meds-off (primary outcome). The therapeutic window was the difference between patients' efficacy and side effect thresholds. Results: The therapeutic window was significantly larger at 30 mu s than 60 mu s (P=.0009) and the efficacy (UPDRS III score) was noninferior (P=.00008). Interpretation: Subthalamic neurostimulation at 30 mu s versus 60 mu s pulse width is equally effective on PD motor signs, is more energy efficient, and has less likelihood of stimulation-related side effects. (c) 2017 The Authors. Movement Disorders published by Wiley Periodicals, Inc. on behalf of International Parkinson and Movement Disorder Society.

Item Type: Journal Article
Creators:
CreatorsEmailORCIDORCID Put Code
Steigerwald, FrankUNSPECIFIEDorcid.org/0000-0002-8305-1684UNSPECIFIED
Timmermann, LarsUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Kuehn, AndreaUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Schnitzler, AlfonsUNSPECIFIEDorcid.org/0000-0002-6414-7939UNSPECIFIED
Reich, Martin M.UNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Kirsch, Anna DalalUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Barbe, Michael ThomasUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Visser-Vandewalle, VeerleUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Huebl, JuliusUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
van Riesen, ChristophUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Groiss, Stefan JunUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Moldovan, Alexia-SabineUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Lin, SherryUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Carcieri, StephenUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Manola, LjubomirUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Volkmann, JensUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
URN: urn:nbn:de:hbz:38-200797
DOI: 10.1002/mds.27238
Journal or Publication Title: Mov. Disord.
Volume: 33
Number: 1
Page Range: S. 165 - 170
Date: 2018
Publisher: WILEY
Place of Publication: HOBOKEN
ISSN: 1531-8257
Language: English
Faculty: Unspecified
Divisions: Unspecified
Subjects: no entry
Uncontrolled Keywords:
KeywordsLanguage
DEEP BRAIN-STIMULATIONMultiple languages
Clinical NeurologyMultiple languages
Refereed: Yes
URI: http://kups.ub.uni-koeln.de/id/eprint/20079

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