Michely, J., Volz, L. J., Hoffstaedter, F., Tittgemeyer, M., Eickhoff, S. B., Fink, G. R. and Grefkes, C. (2018). Network connectivity of motor control in the ageing brain. NeuroImage-Clin., 18. S. 443 - 456. OXFORD: ELSEVIER SCI LTD. ISSN 2213-1582

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Abstract

Older individuals typically display stronger regional brain activity than younger subjects during motor performance. However, knowledge regarding age-related changes of motor network interactions between brain regions remains scarce. We here investigated the impact of ageing on the interaction of cortical areas during movement selection and initiation using dynamic causal modelling (DCM). We found that age-related psychomotor slowing was accompanied by increases in both regional activity and effective connectivity, especially for 'core' motor coupling targeting primary motor cortex (M1). Interestingly, younger participants within the older group showed strongest connectivity targeting M1, which steadily decreased with advancing age. Conversely, prefrontal influences on the motor system increased with advancing age, and were inversely correlated with reduced parietal influences and core motor coupling. Interestingly, higher net coupling within the prefrontal-premotor- M1 axis predicted faster psychomotor speed in ageing. Hence, as opposed to a uniform age-related decline, our findings are compatible with the idea of different age-related compensatory mechanisms, with an important role of the prefrontal cortex compensating for reduced coupling within the core motor network.

Item Type: Journal Article
Creators:
CreatorsEmailORCIDORCID Put Code
Michely, J.UNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Volz, L. J.UNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Hoffstaedter, F.UNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Tittgemeyer, M.UNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Eickhoff, S. B.UNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Fink, G. R.UNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Grefkes, C.UNSPECIFIEDUNSPECIFIEDUNSPECIFIED
URN: urn:nbn:de:hbz:38-200867
DOI: 10.1016/j.nicl.2018.02.001
Journal or Publication Title: NeuroImage-Clin.
Volume: 18
Page Range: S. 443 - 456
Date: 2018
Publisher: ELSEVIER SCI LTD
Place of Publication: OXFORD
ISSN: 2213-1582
Language: English
Faculty: Unspecified
Divisions: Unspecified
Subjects: no entry
Uncontrolled Keywords:
KeywordsLanguage
AGE-RELATED-CHANGES; POSTERIOR PARIETAL CORTEX; PREFRONTAL CORTEX; HEMISPHERIC-ASYMMETRY; PARKINSONS-DISEASE; FRONTOPARIETAL NETWORK; CORTICAL CONNECTIVITY; EXECUTIVE FUNCTIONS; MEMORY PERFORMANCE; VISUAL-ATTENTIONMultiple languages
NeuroimagingMultiple languages
Refereed: Yes
URI: http://kups.ub.uni-koeln.de/id/eprint/20086

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