Universität zu Köln

Kusch, M., Schmidt, C. C., Goeden, L., Tscherpel, C., Stahl, J., Saliger, J., Karbe, H., Fink, G. R. and Weiss, P. H. (2018). Recovery from apraxic deficits and its neural correlate. Restor. Neurol. Neurosci., 36 (6). S. 669 - 679. AMSTERDAM: IOS PRESS. ISSN 1878-3627

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Abstract

Background and Objective: Apraxia is a deficit of motor cognition leading to difficulties in actual tool use, imitation of gestures, and pantomiming object use. To date, little data exist regarding the recovery from apraxic deficits after stroke, and no statistical lesion mapping study investigated the neural correlate of recovery from apraxia. Accordingly, we here examined recovery from apraxic deficits, differential associations of apraxia task (imitation vs. pantomime) and effector (bucco-facial vs. limb apraxia) with recovery, and the underlying neural correlates. Methods: We assessed apraxia in 39 patients with left hemisphere (LH) stroke both at admission and approximately 11 days later. Furthermore, we collected clinical imaging data to identify brain regions associated with recovery from apraxic deficits using voxel-based lesion-symptom mapping (VLSM). Results: Between the two assessments, a significant recovery from apraxic deficits was observed with a tendency of enhanced recovery of limb compared to bucco-facial apraxia. VLSM analyses revealed that within the lesion pattern initially associated with apraxia, lesions of the left insula were associated with remission of apraxic deficits, whereas lesions to the (inferior) parietal lobe (IPL; supramarginal and angular gyrus) and the superior longitudinal fasciculus (SLF) were associated with persistent apraxic deficits. Conclusions: Data suggest that lesions affecting the core regions (and white matter) of the fronto-parietal praxis network cause more persistent apraxic deficits than lesions affecting other regions (here: the left insula) that also contribute to motor cognition and apraxic deficits.

Item Type:	Journal Article
Creators:	Creators Email ORCID ORCID Put Code Kusch, M. UNSPECIFIED UNSPECIFIED UNSPECIFIED Schmidt, C. C. UNSPECIFIED UNSPECIFIED UNSPECIFIED Goeden, L. UNSPECIFIED UNSPECIFIED UNSPECIFIED Tscherpel, C. UNSPECIFIED UNSPECIFIED UNSPECIFIED Stahl, J. UNSPECIFIED UNSPECIFIED UNSPECIFIED Saliger, J. UNSPECIFIED UNSPECIFIED UNSPECIFIED Karbe, H. UNSPECIFIED UNSPECIFIED UNSPECIFIED Fink, G. R. UNSPECIFIED UNSPECIFIED UNSPECIFIED Weiss, P. H. UNSPECIFIED UNSPECIFIED UNSPECIFIED
URN:	urn:nbn:de:hbz:38-201041
DOI:	10.3233/RNN-180815
Journal or Publication Title:	Restor. Neurol. Neurosci.
Volume:	36
Number:	6
Page Range:	S. 669 - 679
Date:	2018
Publisher:	IOS PRESS
Place of Publication:	AMSTERDAM
ISSN:	1878-3627
Language:	English
Faculty:	Unspecified
Divisions:	Unspecified
Subjects:	no entry
Uncontrolled Keywords:	Keywords Language LONG-TERM RECOVERY; STROKE PATIENTS; PANTOMIME; AWARENESS Multiple languages Neurosciences Multiple languages
Refereed:	Yes
URI:	http://kups.ub.uni-koeln.de/id/eprint/20104