Lewczuk, Piotr ORCID: 0000-0002-8101-6535, Riederer, Peter, O'Bryant, Sid E., Verbeek, Marcel M., Dubois, Bruno, Visser, Pieter Jelle ORCID: 0000-0001-8008-9727, Jellinger, Kurt A., Engelborghs, Sebastiaan, Ramirez, Alfredo ORCID: 0000-0003-4991-763X, Parnetti, Lucilla ORCID: 0000-0001-5722-3967, Jack, Clifford R., Jr., Teunissen, Charlotte E., Hampel, Harald, Lleo, Alberto, Jessen, Frank, Glodzik, Lidia, de Leon, Mony J., Fagan, Anne M., Luis Molinuevo, Jose, Jansen, Willemijn J., Winblad, Bengt, Shaw, Leslie M., Andreasson, Ulf, Otto, Markus ORCID: 0000-0003-4273-4267, Mollenhauer, Brit, Wiltfang, Jens ORCID: 0000-0003-1492-5330, Turner, Martin R., Zerr, Inga, Handels, Ron ORCID: 0000-0002-8663-0630, Thompson, Alexander G., Johansson, Gunilla, Ermann, Natalia, Trojanowski, John Q., Karaca, Ilker, Wagner, Holger, Oeckl, Patrick ORCID: 0000-0002-7652-7023, van Doorn, Linda van Waalwijk, Bjerke, Maria, Kapogiannis, Dimitrios ORCID: 0000-0003-2181-3118, Kuiperij, H. Bea, Farotti, Lucia, Li, Yi, Gordon, Brian A., Epelbaum, Stephane ORCID: 0000-0003-4059-2891, Vos, Stephanie J. B., Klijn, Catharina J. M., Van Nostrand, William E., Minguillon, Carolina, Schmitz, Matthias, Gallo, Carla ORCID: 0000-0001-8348-0473, Mato, Andrea Lopez, Thibaut, Florence, Lista, Simone, Alcolea, Daniel ORCID: 0000-0002-3819-3245, Zetterberg, Henrik, Blennow, Kaj and Kornhuber, Johannes ORCID: 0000-0002-8096-3987 (2018). Cerebrospinal fluid and blood biomarkers for neurodegenerative dementias: An update of the Consensus of the Task Force on Biological Markers in Psychiatry of the World Federation of Societies of Biological Psychiatry. World J. Biol. Psychiatry, 19 (4). S. 244 - 329. ABINGDON: TAYLOR & FRANCIS LTD. ISSN 1814-1412

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Abstract

In the 12 years since the publication of the first Consensus Paper of the WFSBP on biomarkers of neurodegenerative dementias, enormous advancement has taken place in the field, and the Task Force takes now the opportunity to extend and update the original paper. New concepts of Alzheimer's disease (AD) and the conceptual interactions between AD and dementia due to AD were developed, resulting in two sets for diagnostic/research criteria. Procedures for pre-analytical sample handling, biobanking, analyses and post-analytical interpretation of the results were intensively studied and optimised. A global quality control project was introduced to evaluate and monitor the inter-centre variability in measurements with the goal of harmonisation of results. Contexts of use and how to approach candidate biomarkers in biological specimens other than cerebrospinal fluid (CSF), e.g. blood, were precisely defined. Important development was achieved in neuroimaging techniques, including studies comparing amyloid- positron emission tomography results to fluid-based modalities. Similarly, development in research laboratory technologies, such as ultra-sensitive methods, raises our hopes to further improve analytical and diagnostic accuracy of classic and novel candidate biomarkers. Synergistically, advancement in clinical trials of anti-dementia therapies energises and motivates the efforts to find and optimise the most reliable early diagnostic modalities. Finally, the first studies were published addressing the potential of cost-effectiveness of the biomarkers-based diagnosis of neurodegenerative disorders.

Item Type: Journal Article
Creators:
CreatorsEmailORCIDORCID Put Code
Lewczuk, PiotrUNSPECIFIEDorcid.org/0000-0002-8101-6535UNSPECIFIED
Riederer, PeterUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
O'Bryant, Sid E.UNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Verbeek, Marcel M.UNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Dubois, BrunoUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Visser, Pieter JelleUNSPECIFIEDorcid.org/0000-0001-8008-9727UNSPECIFIED
Jellinger, Kurt A.UNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Engelborghs, SebastiaanUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Ramirez, AlfredoUNSPECIFIEDorcid.org/0000-0003-4991-763XUNSPECIFIED
Parnetti, LucillaUNSPECIFIEDorcid.org/0000-0001-5722-3967UNSPECIFIED
Jack, Clifford R., Jr.UNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Teunissen, Charlotte E.UNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Hampel, HaraldUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Lleo, AlbertoUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Jessen, FrankUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Glodzik, LidiaUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
de Leon, Mony J.UNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Fagan, Anne M.UNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Luis Molinuevo, JoseUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Jansen, Willemijn J.UNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Winblad, BengtUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Shaw, Leslie M.UNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Andreasson, UlfUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Otto, MarkusUNSPECIFIEDorcid.org/0000-0003-4273-4267UNSPECIFIED
Mollenhauer, BritUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Wiltfang, JensUNSPECIFIEDorcid.org/0000-0003-1492-5330UNSPECIFIED
Turner, Martin R.UNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Zerr, IngaUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Handels, RonUNSPECIFIEDorcid.org/0000-0002-8663-0630UNSPECIFIED
Thompson, Alexander G.UNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Johansson, GunillaUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Ermann, NataliaUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Trojanowski, John Q.UNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Karaca, IlkerUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Wagner, HolgerUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Oeckl, PatrickUNSPECIFIEDorcid.org/0000-0002-7652-7023UNSPECIFIED
van Doorn, Linda van WaalwijkUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Bjerke, MariaUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Kapogiannis, DimitriosUNSPECIFIEDorcid.org/0000-0003-2181-3118UNSPECIFIED
Kuiperij, H. BeaUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Farotti, LuciaUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Li, YiUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Gordon, Brian A.UNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Epelbaum, StephaneUNSPECIFIEDorcid.org/0000-0003-4059-2891UNSPECIFIED
Vos, Stephanie J. B.UNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Klijn, Catharina J. M.UNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Van Nostrand, William E.UNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Minguillon, CarolinaUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Schmitz, MatthiasUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Gallo, CarlaUNSPECIFIEDorcid.org/0000-0001-8348-0473UNSPECIFIED
Mato, Andrea LopezUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Thibaut, FlorenceUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Lista, SimoneUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Alcolea, DanielUNSPECIFIEDorcid.org/0000-0002-3819-3245UNSPECIFIED
Zetterberg, HenrikUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Blennow, KajUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Kornhuber, JohannesUNSPECIFIEDorcid.org/0000-0002-8096-3987UNSPECIFIED
URN: urn:nbn:de:hbz:38-201109
DOI: 10.1080/15622975.2017.1375556
Journal or Publication Title: World J. Biol. Psychiatry
Volume: 19
Number: 4
Page Range: S. 244 - 329
Date: 2018
Publisher: TAYLOR & FRANCIS LTD
Place of Publication: ABINGDON
ISSN: 1814-1412
Language: English
Faculty: Unspecified
Divisions: Unspecified
Subjects: no entry
Uncontrolled Keywords:
KeywordsLanguage
MILD COGNITIVE IMPAIRMENT; CREUTZFELDT-JAKOB-DISEASE; FRONTOTEMPORAL LOBAR DEGENERATION; AMYOTROPHIC-LATERAL-SCLEROSIS; CEREBRAL AMYLOID ANGIOPATHY; ALZHEIMERS ASSOCIATION WORKGROUPS; NEUROFILAMENT LIGHT-CHAIN; GAMMA-SECRETASE INHIBITOR; CSF ALPHA-SYNUCLEIN; SUBJECTIVE MEMORY COMPLAINTSMultiple languages
PsychiatryMultiple languages
Refereed: Yes
URI: http://kups.ub.uni-koeln.de/id/eprint/20110

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