Universität zu Köln

Gao, Haihe ORCID: 0000-0002-1853-8824, Li, Lisha, Xiao, Mang, Guo, Yongwei ORCID: 0000-0001-9195-0770, Shen, Yi, Cheng, Lixin and Tang, Ming (2018). Elevated DKK1 expression is an independent unfavorable prognostic indicator of survival in head and neck squamous cell carcinoma. Cancer Manag. Res., 10. S. 5083 - 5090. ALBANY: DOVE MEDICAL PRESS LTD. ISSN 1179-1322

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Abstract

Purpose: DKK1 is an antagonist of the Wnt signaling pathway that has various roles in human physiology. Notably, aberrant DKK1 expression is observed in several cancers. In this retrospective study, we assessed the association between DKK1 expression levels and head and neck squamous cell carcinoma (HNSCC) and its prognostic value. Materials and methods: Using RNA-seq data from HNSCC tumors (N=520) and adjacent normal tissue (N=44) in The Cancer Genome Atlas, we evaluated DKK1 expression levels. Additionally, we evaluated the association of DKK1 expression levels and pathophysiological features of patients with HNSCC and the value of DKK1 expression for prediction of overall survival (OS). We also explored the correlation between DKK1 expression and methylation of its promoter in HNSCC. Results: DKK1 expression was significantly upregulated in HNSCC compared with normal tissues. Moreover, DKK1 expression was significantly associated with smoking, alcohol abuse, sex, human papillomavirus status, tumor site, tumor invasion, and pathologic stage in HNSCC patients. Kaplan-Meier curves showed that high DKK1 expression was correlated with inferior OS. In addition, univariate and multivariate analyses showed that elevated DKK1 expression was an independent prognostic factor for poor OS (HR: 1.85, 95% CI: 1.31-2.62, P<0.001). Regression analysis identified a strong negative correlation between DKK1 expression and methylation of its promoter. Conclusion: These findings support the hypothesis that elevated DKK1 expression is modulated via methylation of its promoter and indicate that DKK1 expression is a highly informative prognostic biomarker for patients with HNSCC.

Item Type:	Journal Article
Creators:	Creators Email ORCID ORCID Put Code Gao, Haihe UNSPECIFIED orcid.org/0000-0002-1853-8824 UNSPECIFIED Li, Lisha UNSPECIFIED UNSPECIFIED UNSPECIFIED Xiao, Mang UNSPECIFIED UNSPECIFIED UNSPECIFIED Guo, Yongwei UNSPECIFIED orcid.org/0000-0001-9195-0770 UNSPECIFIED Shen, Yi UNSPECIFIED UNSPECIFIED UNSPECIFIED Cheng, Lixin UNSPECIFIED UNSPECIFIED UNSPECIFIED Tang, Ming UNSPECIFIED UNSPECIFIED UNSPECIFIED
URN:	urn:nbn:de:hbz:38-201283
DOI:	10.2147/CMAR.S177043
Journal or Publication Title:	Cancer Manag. Res.
Volume:	10
Page Range:	S. 5083 - 5090
Date:	2018
Publisher:	DOVE MEDICAL PRESS LTD
Place of Publication:	ALBANY
ISSN:	1179-1322
Language:	English
Faculty:	Unspecified
Divisions:	Unspecified
Subjects:	no entry
Uncontrolled Keywords:	Keywords Language CANCER STATISTICS; SERUM DICKKOPF-1; WNT PATHWAY; METHYLATION; EPIDEMIOLOGY; PROGRESSION; DIAGNOSIS; BIOMARKER; TUMOR; STAGE Multiple languages Oncology Multiple languages
Refereed:	Yes
URI:	http://kups.ub.uni-koeln.de/id/eprint/20128