Universität zu Köln

Hami, Louisa T., Lampe, Bjoern, Mallmann, Peter and Forner, Dirk M. (2018). The Impact of Age on the Prognosis of Vulvar Cancer. Oncol. Res. Treat., 41 (9). S. 520 - 525. BASEL: KARGER. ISSN 2296-5262

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Abstract

Introduction: Younger women are particularly affected by the increase in the incidence of vulvar cancer. The purpose of this study was to investigate how clinical characteristics differ depending on the patient's age and what role the age of initial diagnosis plays in the prognosis. Patients and Methods: Included patients were divided into groups aged below or above 50 years. The disease-free survival (DFS) was calculated and a multivariate discriminant analysis was conducted. Results: Of the 300 patients, 79 were <= 50 years and 221 were >50 years. The median age was 64 years (19-96 years). There were no differences between the groups regarding lymph node (LN) status and distant metastasis, but T1 tumours were more frequent in patients <= 50 years (77% vs. 62%, p = 0.02). The DFS only differed between the groups when there were no LN metastases. The nodal status was the predominant prognostic factor for the DFS regardless of age. In node-free patients, the 5-year DFS was 49% for the <= 50 years group and 89% for the >50 years group (p = 0.008), whereas there was no difference if a LN was involved. Conclusion: In node-free patients, the risk for recurrence is lower for patients older than 50 years. (c) 2018 S. Karger GmbH, Freiburg

Item Type:	Journal Article
Creators:	Creators Email ORCID ORCID Put Code Hami, Louisa T. UNSPECIFIED UNSPECIFIED UNSPECIFIED Lampe, Bjoern UNSPECIFIED UNSPECIFIED UNSPECIFIED Mallmann, Peter UNSPECIFIED UNSPECIFIED UNSPECIFIED Forner, Dirk M. UNSPECIFIED UNSPECIFIED UNSPECIFIED
URN:	urn:nbn:de:hbz:38-202048
DOI:	10.1159/000488800
Journal or Publication Title:	Oncol. Res. Treat.
Volume:	41
Number:	9
Page Range:	S. 520 - 525
Date:	2018
Publisher:	KARGER
Place of Publication:	BASEL
ISSN:	2296-5262
Language:	English
Faculty:	Unspecified
Divisions:	Unspecified
Subjects:	no entry
Uncontrolled Keywords:	Keywords Language SQUAMOUS-CELL CARCINOMA; HUMAN-PAPILLOMAVIRUS; RISK-FACTORS; RECURRENCE; LYMPHADENECTOMY; HPV; SURVIVAL; THERAPY; NUMBER; WOMEN Multiple languages Oncology Multiple languages
Refereed:	Yes
URI:	http://kups.ub.uni-koeln.de/id/eprint/20204