Universität zu Köln

Ophey, Anja ORCID: 0000-0001-5858-7762, Eggers, Carsten, Dano, Richard, Timmermann, Lars and Kalbe, Elke (2018). Health-Related Quality of Life Subdomains in Patients with Parkinson's Disease: The Role of Gender. Parkinsons Dis., 2018. LONDON: HINDAWI LTD. ISSN 2042-0080

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Abstract

The most frequently used instrument to assess health-related quality of life (HrQoL) in Parkinson's disease (PD) is the Parkinson's Disease Questionnaire 39 (PDQ-39). However, both the dimensionality of the eight PDQ-39 subscales and their summary score recently faced criticism. Furthermore, data on disease-related and neuropsychological determinants and the role of gender on HrQoL in PD are inconclusive yet. Therefore, our aim was to reevaluate the PDQ-39 structure and to further explore determinants of HrQoL, in PD. 245 PD patients (age: M = 69.64, SD = 8.43; 62.9% male; H&Y: Md = 3.00; cognitive assessment with PANDA: M. 24.82, SD = 3.57) from the baseline database of the Cologne Parkinson Network were used to reevaluate the dimensionality of the PDQ-39 with a principal component analysis (PCA). Multiple regression analyses were conducted to clarify general and domain-specific relationships between clinical, (neuro)psychological, and sociodemographic variables, gender in particular, and HrQoL. The PCA identified three HrQoL domains: physical-functioning, cognition, and socioemotional HrQoL. Depressive symptoms were identified as the most important determinant of HrQoL across all models. Disease-related HrQoL determinants (UPDRS-III, H&Y stage, and LEDD) were less strong and consistent HrQoL determinants than nonmotor symptoms. Analyses did not reveal a global gender effect; however, female gender was a negative predictor for physical-functioning and socioemotional HrQoL, whereas male gender was a negative predictor for cognition HrQoL. Our analyses suggest the consideration of a reevaluation of the PDQ-39. Only the full understanding of HrQoL, its determinants, and their interrelationships will allow the development of PD intervention strategies focusing on what matters the most for patients' I IrQoL. Gender is one relevant variable that should be considered in this context.

Item Type:	Journal Article
Creators:	Creators Email ORCID ORCID Put Code Ophey, Anja UNSPECIFIED orcid.org/0000-0001-5858-7762 UNSPECIFIED Eggers, Carsten UNSPECIFIED UNSPECIFIED UNSPECIFIED Dano, Richard UNSPECIFIED UNSPECIFIED UNSPECIFIED Timmermann, Lars UNSPECIFIED UNSPECIFIED UNSPECIFIED Kalbe, Elke UNSPECIFIED UNSPECIFIED UNSPECIFIED
URN:	urn:nbn:de:hbz:38-202244
DOI:	10.1155/2018/6532320
Journal or Publication Title:	Parkinsons Dis.
Volume:	2018
Date:	2018
Publisher:	HINDAWI LTD
Place of Publication:	LONDON
ISSN:	2042-0080
Language:	English
Faculty:	Unspecified
Divisions:	Unspecified
Subjects:	no entry
Uncontrolled Keywords:	Keywords Language COGNITIVE IMPAIRMENT; NONMOTOR SYMPTOMS; PDQ-39; IMPACT; RELIABILITY; DEPRESSION; VALIDATION; DISABILITY; VALIDITY; PEOPLE Multiple languages Clinical Neurology Multiple languages
Refereed:	Yes
URI:	http://kups.ub.uni-koeln.de/id/eprint/20224