Universität zu Köln

Willkommen, Desiree, Lucio, Marianna ORCID: 0000-0002-5844-0098, Schmitt-Kopplin, Philippe ORCID: 0000-0003-0824-2664, Gazzaz, Malaz, Schroeter, Michael, Sigaroudi, Ali ORCID: 0000-0002-3176-4631 and Michalke, Bernhard (2018). Species fractionation in a case-control study concerning Parkinson's disease: Cu-amino acids discriminate CSF of PD from controls. J. Trace Elem. Med. Biol., 49. S. 164 - 171. MUNICH: ELSEVIER GMBH. ISSN 0946-672X

Full text not available from this repository.

Abstract

Background: Parkinson's disease is affecting about 1% of the population above 65 years. Improvements in medicine support prolonged lifetime which increases the total concentration of humans affected by the disease. It is suggested that occupational and environmental exposure to metals like iron (Fe), manganese (Mn), copper (Cu) and zinc (Zn) can influence the risk for Parkinson's disease. These metals play a key role as cofactors in many enzymes and proteins. Methods: In this case-control study, we investigated the Mn-, Fe-, Cu- and Zn-species in cerebrospinal fluid (CSF) by size-exclusion chromatography hyphenated to inductively coupled plasma mass spectrometry (SEC-ICP-MS) and the total concentration of these metals by inductively coupled plasma sector field mass spectrometry (ICP-sf-MS). Results: The investigation of total metal concentration and speciation provided only minor changes, but it produced strong significance for a number of ratios. The analysis revealed a strong change in the ratio between total concentration of Fe and the amino acid-fraction of Cu. This could be observed when analyzing both the respective element concentrations of the fraction (which also depends on individual variation of the total element concentration) as well as when being expressed as percentage of total concentration (normalization) which more clearly shows changes of distribution pattern independent of individual variation of total element concentrations. Conclusion: Speciation analysis, therefore, is a powerful technique to investigate changes in a case-control study where ratios of different species play an important role.

Item Type:	Journal Article
Creators:	Creators Email ORCID ORCID Put Code Willkommen, Desiree UNSPECIFIED UNSPECIFIED UNSPECIFIED Lucio, Marianna UNSPECIFIED orcid.org/0000-0002-5844-0098 UNSPECIFIED Schmitt-Kopplin, Philippe UNSPECIFIED orcid.org/0000-0003-0824-2664 UNSPECIFIED Gazzaz, Malaz UNSPECIFIED UNSPECIFIED UNSPECIFIED Schroeter, Michael UNSPECIFIED UNSPECIFIED UNSPECIFIED Sigaroudi, Ali UNSPECIFIED orcid.org/0000-0002-3176-4631 UNSPECIFIED Michalke, Bernhard UNSPECIFIED UNSPECIFIED UNSPECIFIED
URN:	urn:nbn:de:hbz:38-202302
DOI:	10.1016/j.jtemb.2018.01.005
Journal or Publication Title:	J. Trace Elem. Med. Biol.
Volume:	49
Page Range:	S. 164 - 171
Date:	2018
Publisher:	ELSEVIER GMBH
Place of Publication:	MUNICH
ISSN:	0946-672X
Language:	English
Faculty:	Unspecified
Divisions:	Unspecified
Subjects:	no entry
Uncontrolled Keywords:	Keywords Language CEREBROSPINAL-FLUID; OXIDATIVE STRESS; NEURODEGENERATIVE DISEASES; MANGANESE SPECIATION; ALZHEIMERS-DISEASE; IRON; METALS; COPPER; EXPOSURE; NEUROTOXICITY Multiple languages Biochemistry & Molecular Biology; Endocrinology & Metabolism Multiple languages
Refereed:	Yes
URI:	http://kups.ub.uni-koeln.de/id/eprint/20230