Universität zu Köln

Roheger, Mandy ORCID: 0000-0002-6015-3194, Kalbe, Elke and Liepelt-Scarfone, Inga (2018). Progression of Cognitive Decline in Parkinson's Disease. J. Parkinsons Dis., 8 (2). S. 183 - 194. AMSTERDAM: IOS PRESS. ISSN 1877-718X

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Abstract

Background: Cognitive dysfunction is one of the most prevalent non-motor symptoms in Parkinson's disease (PD), often experienced as more debilitating for patients and caregivers than motor problems. Therefore, a deeper understanding of the course of cognitive decline and the identification of valid progression markers for Parkinson's disease dementia (PDD) is essential. Objective: This systematic review summarizes the current state of knowledge on cognitive decline over time by reporting effect sizes of cognitive changes in neuropsychological tests. Methods: 1368 studies were identified by a PubMed database search and 25 studies by additionally scanning previous literature. After screening all records, including 69 full-text article reviews, 12 longitudinal studies on the progression of cognitive decline in PD met our criteria (e.g., sample size >= 50 patients). Results: Only a few studies monitored cognitive decline over a longer period (> 4 years). Most studies focused on the evaluation of change in global cognitive state by use of the Mini-Mental State Examination, whereas the use of neuropsychological tests was highly heterogenic among studies. Only one study evaluated patients' cognitive performance in all specified domains (executive function, attention & working memory, memory, language, and visual-spatial function) allowing for diagnosis of cognitive impairment according to consensus guidelines. Medium to strong effect sizes could only be observed in studies with follow-up intervals of four years or longer. Conclusions: The results emphasize the need for the assessment of larger PD cohorts over longer periods of follow-up with a comprehensive neuropsychological battery.

Item Type:	Journal Article
Creators:	Creators Email ORCID ORCID Put Code Roheger, Mandy UNSPECIFIED orcid.org/0000-0002-6015-3194 UNSPECIFIED Kalbe, Elke UNSPECIFIED UNSPECIFIED UNSPECIFIED Liepelt-Scarfone, Inga UNSPECIFIED UNSPECIFIED UNSPECIFIED
URN:	urn:nbn:de:hbz:38-202674
DOI:	10.3233/JPD-181306
Journal or Publication Title:	J. Parkinsons Dis.
Volume:	8
Number:	2
Page Range:	S. 183 - 194
Date:	2018
Publisher:	IOS PRESS
Place of Publication:	AMSTERDAM
ISSN:	1877-718X
Language:	English
Faculty:	Unspecified
Divisions:	Unspecified
Subjects:	no entry
Uncontrolled Keywords:	Keywords Language SOCIETY TASK-FORCE; 5-YEAR FOLLOW-UP; QUALITY-OF-LIFE; IMPAIRMENT; DEMENTIA; COHORT; MULTICENTER; DEPRESSION; PREDICTION; DEFICITS Multiple languages Neurosciences Multiple languages
Refereed:	Yes
URI:	http://kups.ub.uni-koeln.de/id/eprint/20267