Universität zu Köln

Boucher, Charles A., Bobkova, Marina R., Hung, Chien-Ching, Kaiser, Rolf, Marcelin, Anne-Genevieve, Streinu-Cercel, Adrian ORCID: 0000-0001-6382-5067, van Wyk, Jean, Dorr, Pat and Vandamme, Anne-Mieke ORCID: 0000-0002-6594-2766 (2018). State of the Antiretroviral Therapy in Human Immunodeficiency Virus Drug Resistance: Surveillance and Regional Gaps. Aids Rev., 20 (1). S. 42 - 57. BARCELONA: PERMANYER PUBL. ISSN 1698-6997

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Abstract

This article is the second of a two-part review aiming to identify gaps in the knowledge and management of human immunodeficiency virus type 1 drug resistance (HIVDR) from global and regional perspectives. Here, we examine the policy and programmatic gaps in HIVDR surveillance, the affected populations and settings, and implications for clinical practice. The expert authorship of this review convened to identify gaps in HIVDR surveillance, with a particular focus on specific regional variations within and between Europe and Asia, to highlight directions for research and implementation. Further, evidence was gathered from a review of published studies, guidelines, and current practices. This review found that despite recent progress in the development, harmonization, and implementation of guidelines on HIVDR reporting and surveillance, programmatic, and policy gaps reflect the regional variability in HIV epidemics, clinical practice, and resources. The need for representative surveillance was identified as a key gap that has the -potential to inform management policies. Monitoring must keep up with the evolution of transmission routes to adapt appropriately, and this will be further impacted by migration from areas with increasing levels of resistance. Analysis of the latest clinical data, regional practice, policy, and guidelines has identified a number of gaps in HIVDR population monitoring and surveillance. More efforts are needed to align surveillance platforms with harm reduction and patient education, particularly in vulnerable subgroups. Addressing these gaps will facilitate research into and progress in the management of HIV across a wide range of health-care settings.

Item Type:	Journal Article
Creators:	Creators Email ORCID ORCID Put Code Boucher, Charles A. UNSPECIFIED UNSPECIFIED UNSPECIFIED Bobkova, Marina R. UNSPECIFIED UNSPECIFIED UNSPECIFIED Hung, Chien-Ching UNSPECIFIED UNSPECIFIED UNSPECIFIED Kaiser, Rolf UNSPECIFIED UNSPECIFIED UNSPECIFIED Marcelin, Anne-Genevieve UNSPECIFIED UNSPECIFIED UNSPECIFIED Streinu-Cercel, Adrian UNSPECIFIED orcid.org/0000-0001-6382-5067 UNSPECIFIED van Wyk, Jean UNSPECIFIED UNSPECIFIED UNSPECIFIED Dorr, Pat UNSPECIFIED UNSPECIFIED UNSPECIFIED Vandamme, Anne-Mieke UNSPECIFIED orcid.org/0000-0002-6594-2766 UNSPECIFIED
URN:	urn:nbn:de:hbz:38-203005
DOI:	10.24875/AIDSRev.M18000019
Journal or Publication Title:	Aids Rev.
Volume:	20
Number:	1
Page Range:	S. 42 - 57
Date:	2018
Publisher:	PERMANYER PUBL
Place of Publication:	BARCELONA
ISSN:	1698-6997
Language:	English
Faculty:	Unspecified
Divisions:	Unspecified
Subjects:	no entry
Uncontrolled Keywords:	Keywords Language NON-B SUBTYPES; HIV-1 SUBTYPE; 1ST-LINE REGIMENS; EASTERN-EUROPE; INDIVIDUALS; TRANSMISSION; MUTATIONS; INFECTION; DIVERSITY; VARIANTS Multiple languages Immunology; Infectious Diseases Multiple languages
Refereed:	Yes
URI:	http://kups.ub.uni-koeln.de/id/eprint/20300