Universität zu Köln

Huenlich, M., Lubos, E., Beuthner, B. E., Puls, M., Bleckmann, A., Beissbarth, T., Tichelbaecker, T., Rudolph, V., Baldus, S., Schaefer, U., Treede, H., Von Bardeleben, R. S., Blankenberg, S. and Schillinger, W. (2018). Acute and Long-Term Hemodynamic Effects of MitraClip Implantation on a Preexisting Secondary Right Heart Failure. Biomed Res. Int., 2018. LONDON: HINDAWI LTD. ISSN 2314-6141

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Abstract

Positive results of MitraClip in terms of improvement in clinical and left ventricular parameters have been described in detail. However, long-term effects on secondary pulmonary hypertension were not investigated in a larger patient cohort to date. 70 patients with severe mitral regurgitation, additional pulmonary hypertension, and right heart failure as a result of left heart disease were treated in the heart centers Hamburg and Gottingen. Immediately after successful MitraClip implantation, a reduction of the RVOT diameter from 3.52 cm to 3.44 cm was observed reaching a statistically significant value of 3.39 cm after 12 months. In contrast, there was a significant reduction in the velocity of the tricuspid regurgitation (TR) from 4.17 m/s to 3.11 m/s, the gradient of the TR from 48.5 mmHg to 39.3 mmHg, and the systolic pulmonary artery pressure (PAPsyst) from 58.6 mmHg to 50.0 mmHg. This decline continued in the following months (V-max TR 3.09 m/s, peak TR 38.6 mmHg, and PAPsyst 47.4 mmHg). The tricuspid annular plane systolic excursion (TAPSE) increased from 16.5 mm to 18.9 mm after 12 months. MitraClip implantation improves pulmonary artery pressure, tricuspid regurgitation, and TAPSE after 12 months. At the same time, there is a decrease in the RVOT diameter without significant changes in other right ventricular and right atrial dimensions.

Item Type:	Journal Article
Creators:	Creators Email ORCID ORCID Put Code Huenlich, M. UNSPECIFIED UNSPECIFIED UNSPECIFIED Lubos, E. UNSPECIFIED UNSPECIFIED UNSPECIFIED Beuthner, B. E. UNSPECIFIED UNSPECIFIED UNSPECIFIED Puls, M. UNSPECIFIED UNSPECIFIED UNSPECIFIED Bleckmann, A. UNSPECIFIED UNSPECIFIED UNSPECIFIED Beissbarth, T. UNSPECIFIED UNSPECIFIED UNSPECIFIED Tichelbaecker, T. UNSPECIFIED UNSPECIFIED UNSPECIFIED Rudolph, V. UNSPECIFIED UNSPECIFIED UNSPECIFIED Baldus, S. UNSPECIFIED UNSPECIFIED UNSPECIFIED Schaefer, U. UNSPECIFIED UNSPECIFIED UNSPECIFIED Treede, H. UNSPECIFIED UNSPECIFIED UNSPECIFIED Von Bardeleben, R. S. UNSPECIFIED UNSPECIFIED UNSPECIFIED Blankenberg, S. UNSPECIFIED UNSPECIFIED UNSPECIFIED Schillinger, W. UNSPECIFIED UNSPECIFIED UNSPECIFIED
URN:	urn:nbn:de:hbz:38-203396
DOI:	10.1155/2018/6817832
Journal or Publication Title:	Biomed Res. Int.
Volume:	2018
Date:	2018
Publisher:	HINDAWI LTD
Place of Publication:	LONDON
ISSN:	2314-6141
Language:	English
Faculty:	Unspecified
Divisions:	Unspecified
Subjects:	no entry
Uncontrolled Keywords:	Keywords Language RIGHT-VENTRICULAR FUNCTION; VALVE REPAIR; PULMONARY-HYPERTENSION; SYSTOLIC FUNCTION; REGURGITATION; GUIDELINES; DISEASE; DYSFUNCTION; MANAGEMENT; PRESSURE Multiple languages Biotechnology & Applied Microbiology; Medicine, Research & Experimental Multiple languages
Refereed:	Yes
URI:	http://kups.ub.uni-koeln.de/id/eprint/20339