Universität zu Köln

Kauke, Martin, Safi, Ali-Farid, Kreppel, Matthias, Grandoch, Andrea, Nickenig, Hans-Joachim, Zoeller, Joachim E. and Dreiseidler, Timo (2018). Size distribution and clinicoradiological signs of aggressiveness in odontogenic myxoma-three-dimensional analysis and systematic review. Dentomaxillofac. Radiol., 47 (2). LONDON: BRITISH INST RADIOLOGY. ISSN 1476-542X

Full text not available from this repository.

Abstract

Objectives: Therapeutic assessment of odontogenic myxoma (OM) is poorly standardized. Unidimensional size criteria have shown to be unreliable in therapeutic decision-making. We evaluate the size distribution of OM and scan for associated clinicoradiological signs of aggressiveness. Additionally, we evaluate three-dimensional size delineation of OM aiming to improve future therapeutic assessment of this destructive neoplasm. Methods: Primarily, we reviewed the database PubMed for data concerning the size of OMs as radiologically determined. Afterwards, the impact of age, sex, locularity and location on the size was investigated by chi(2) test, Student's t-test and regression analysis. Furthermore, we statistically evaluated the impact of size on the occurrence of clinicoradiological signs of aggressiveness. Secondly, we approximated the volume of five unpublished cases of OM by semi-automatic image segmentation of cone-beam CT images. Results: Multilocular OMs were significantly larger than unilocular ones (p < 0.002). Age (0.042) and multilocularity (< 0.002) significantly impacted size. Size was significantly associated with cortical perforation (0.032) and multilocularity (< 0.002), further regression analysis revealed tooth resorption (0.019), cortical perforation (0.005) and multilocularity (< 0.002) as significant predictors of size. Employing the volume as a mean of comparison, we found that the biggest OM (38.42 ml; multilocular) was 124 times larger than the smallest (0.31 ml; unilocular). However, using the maximum diameter (cm) as a surrogate for size, the biggest lesion (6.3) was only 5.25 times larger than the smallest (1.2). Conclusions: Locularity and volumetric size characterization might help in therapeutic decision-making and could help to improve our understanding of OM.

Item Type:	Journal Article
Creators:	Creators Email ORCID ORCID Put Code Kauke, Martin UNSPECIFIED UNSPECIFIED UNSPECIFIED Safi, Ali-Farid UNSPECIFIED UNSPECIFIED UNSPECIFIED Kreppel, Matthias UNSPECIFIED UNSPECIFIED UNSPECIFIED Grandoch, Andrea UNSPECIFIED UNSPECIFIED UNSPECIFIED Nickenig, Hans-Joachim UNSPECIFIED UNSPECIFIED UNSPECIFIED Zoeller, Joachim E. UNSPECIFIED UNSPECIFIED UNSPECIFIED Dreiseidler, Timo UNSPECIFIED UNSPECIFIED UNSPECIFIED
URN:	urn:nbn:de:hbz:38-204330
DOI:	10.1259/dmfr.20170262
Journal or Publication Title:	Dentomaxillofac. Radiol.
Volume:	47
Number:	2
Date:	2018
Publisher:	BRITISH INST RADIOLOGY
Place of Publication:	LONDON
ISSN:	1476-542X
Language:	English
Faculty:	Unspecified
Divisions:	Unspecified
Subjects:	no entry
Uncontrolled Keywords:	Keywords Language MYXOMA; TUMORS; SEGMENTATION; FEATURES Multiple languages Dentistry, Oral Surgery & Medicine; Radiology, Nuclear Medicine & Medical Imaging Multiple languages
Refereed:	Yes
URI:	http://kups.ub.uni-koeln.de/id/eprint/20433