Enders, Philip 
ORCID: 0000-0002-9527-4957, Sitnilska, Vasilena, Altay, Lebriz and Fauser, Sascha
(2018).
Early Changes of Retinal Morphology in Therapy of Neovascular Age-Related Macular Degeneration with Three Commonly Used Anti-VEGF Agents.
Ophthalmologica, 239 (1).
S. 45 - 52.
BASEL:
KARGER.
ISSN 1423-0267
Abstract
Purpose: To compare changes of retinal morphology in the first weeks following injection of anti-VEGF agents for neovascular age-related macular degeneration (nAMD). Procedures: In a prospective study 50 patients with active choroidal neovascularization secondary to nAMD were monitored weekly by spectral-domain optical coherence tomography for 3 weeks after treatment. Twenty-two patients received bevacizumab, 15 ranibizumab, and 13 aflibercept. Morphological parameters of retinal compartments were compared. Results: Mean central retinal thickness (391.22 +/- 123.41 mu m) was reduced by -26.15 mu m (p < 0.001) after 1 week, by -12.54 mu m (p < 0.001) after 2 weeks, and by -3.52 mu m (p = 0.09) after 3 weeks. Mean intraretinal layer thickness changed only significantly between baseline and week 1 (p < 0.001). Mean subretinal thickness also decreased between weeks 1 and 2 (p = 0.01). Conclusions: Early morphological changes occur primarily in the first 14 days after treatment. This information could be clinically helpful to evaluate early non-response. (C) 2017 S. Karger AG, Basel
| Item Type: | Journal Article | ||||||||||||||||||||
| Creators: |
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| URN: | urn:nbn:de:hbz:38-204913 | ||||||||||||||||||||
| DOI: | 10.1159/000480356 | ||||||||||||||||||||
| Journal or Publication Title: | Ophthalmologica | ||||||||||||||||||||
| Volume: | 239 | ||||||||||||||||||||
| Number: | 1 | ||||||||||||||||||||
| Page Range: | S. 45 - 52 | ||||||||||||||||||||
| Date: | 2018 | ||||||||||||||||||||
| Publisher: | KARGER | ||||||||||||||||||||
| Place of Publication: | BASEL | ||||||||||||||||||||
| ISSN: | 1423-0267 | ||||||||||||||||||||
| Language: | English | ||||||||||||||||||||
| Faculty: | Unspecified | ||||||||||||||||||||
| Divisions: | Unspecified | ||||||||||||||||||||
| Subjects: | no entry | ||||||||||||||||||||
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| Refereed: | Yes | ||||||||||||||||||||
| URI: | http://kups.ub.uni-koeln.de/id/eprint/20491 |
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