Universität zu Köln

Hutterer, Markus, Bumes, Elisabeth, Riemenschneider, Markus J., Grosse, Jirka, Hellwig, Dirk ORCID: 0000-0002-3056-0143, Galldiks, Norbert ORCID: 0000-0002-2485-1796, Langen, Karl-Josef ORCID: 0000-0003-1101-5075 and Hau, Peter ORCID: 0000-0003-3894-5053 (2017). AIDS-Related Central Nervous System Toxoplasmosis With Increased 18F-Fluoroethyl-l-Tyrosine Amino Acid PET Uptake Due to LAT1/2 Expression of Inflammatory Cells. Clin. Nucl. Med., 42 (12). S. E506 - 3. PHILADELPHIA: LIPPINCOTT WILLIAMS & WILKINS. ISSN 1536-0229

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Abstract

We report the case of a 40-year-old woman with a progressive right-sided hemiparesis. Standard MRI revealed a contrast-enhancing brain lesion within the left basal ganglia. (18)Ffluoroethyl-l-tyrosine (F-18-FET) PET showed a distinct tracer uptake (lesion-to-brain ratio [LBR]: LBRmax = 2.03, LBRmean = 1.68) with a significant larger metabolic lesion volume than contrast-enhancement in MRI, indicating cerebral glioma. Surprisingly, histopathologic analysis demonstrated central nervous system toxoplasmosis with pronounced inflammatory reaction (reactive astrogliosis, microglia activation, macrophage, and T-lymphocyte infiltration), which was associated with strong LAT1/LAT2/CD98 expression. In conclusion, inflammatory brain lesions, such as cerebral toxoplasmosis, represent a potential pitfall of F-18-FET PET mimicking a brain tumor.

Item Type:	Journal Article
Creators:	Creators Email ORCID ORCID Put Code Hutterer, Markus UNSPECIFIED UNSPECIFIED UNSPECIFIED Bumes, Elisabeth UNSPECIFIED UNSPECIFIED UNSPECIFIED Riemenschneider, Markus J. UNSPECIFIED UNSPECIFIED UNSPECIFIED Grosse, Jirka UNSPECIFIED UNSPECIFIED UNSPECIFIED Hellwig, Dirk UNSPECIFIED orcid.org/0000-0002-3056-0143 UNSPECIFIED Galldiks, Norbert UNSPECIFIED orcid.org/0000-0002-2485-1796 UNSPECIFIED Langen, Karl-Josef UNSPECIFIED orcid.org/0000-0003-1101-5075 UNSPECIFIED Hau, Peter UNSPECIFIED orcid.org/0000-0003-3894-5053 UNSPECIFIED
URN:	urn:nbn:de:hbz:38-209708
DOI:	10.1097/RLU.0000000000001873
Journal or Publication Title:	Clin. Nucl. Med.
Volume:	42
Number:	12
Page Range:	S. E506 - 3
Date:	2017
Publisher:	LIPPINCOTT WILLIAMS & WILKINS
Place of Publication:	PHILADELPHIA
ISSN:	1536-0229
Language:	English
Faculty:	Unspecified
Divisions:	Unspecified
Subjects:	no entry
Uncontrolled Keywords:	Keywords Language DIFFERENTIAL UPTAKE; F-18-FLUOROETHYL-L-TYROSINE Multiple languages Radiology, Nuclear Medicine & Medical Imaging Multiple languages
Refereed:	Yes
URI:	http://kups.ub.uni-koeln.de/id/eprint/20970