Hutterer, Markus, Bumes, Elisabeth, Riemenschneider, Markus J., Grosse, Jirka, Hellwig, Dirk ORCID: 0000-0002-3056-0143, Galldiks, Norbert ORCID: 0000-0002-2485-1796, Langen, Karl-Josef ORCID: 0000-0003-1101-5075 and Hau, Peter ORCID: 0000-0003-3894-5053 (2017). AIDS-Related Central Nervous System Toxoplasmosis With Increased 18F-Fluoroethyl-l-Tyrosine Amino Acid PET Uptake Due to LAT1/2 Expression of Inflammatory Cells. Clin. Nucl. Med., 42 (12). S. E506 - 3. PHILADELPHIA: LIPPINCOTT WILLIAMS & WILKINS. ISSN 1536-0229

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Abstract

We report the case of a 40-year-old woman with a progressive right-sided hemiparesis. Standard MRI revealed a contrast-enhancing brain lesion within the left basal ganglia. (18)Ffluoroethyl-l-tyrosine (F-18-FET) PET showed a distinct tracer uptake (lesion-to-brain ratio [LBR]: LBRmax = 2.03, LBRmean = 1.68) with a significant larger metabolic lesion volume than contrast-enhancement in MRI, indicating cerebral glioma. Surprisingly, histopathologic analysis demonstrated central nervous system toxoplasmosis with pronounced inflammatory reaction (reactive astrogliosis, microglia activation, macrophage, and T-lymphocyte infiltration), which was associated with strong LAT1/LAT2/CD98 expression. In conclusion, inflammatory brain lesions, such as cerebral toxoplasmosis, represent a potential pitfall of F-18-FET PET mimicking a brain tumor.

Item Type: Journal Article
Creators:
CreatorsEmailORCIDORCID Put Code
Hutterer, MarkusUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Bumes, ElisabethUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Riemenschneider, Markus J.UNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Grosse, JirkaUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Hellwig, DirkUNSPECIFIEDorcid.org/0000-0002-3056-0143UNSPECIFIED
Galldiks, NorbertUNSPECIFIEDorcid.org/0000-0002-2485-1796UNSPECIFIED
Langen, Karl-JosefUNSPECIFIEDorcid.org/0000-0003-1101-5075UNSPECIFIED
Hau, PeterUNSPECIFIEDorcid.org/0000-0003-3894-5053UNSPECIFIED
URN: urn:nbn:de:hbz:38-209708
DOI: 10.1097/RLU.0000000000001873
Journal or Publication Title: Clin. Nucl. Med.
Volume: 42
Number: 12
Page Range: S. E506 - 3
Date: 2017
Publisher: LIPPINCOTT WILLIAMS & WILKINS
Place of Publication: PHILADELPHIA
ISSN: 1536-0229
Language: English
Faculty: Unspecified
Divisions: Unspecified
Subjects: no entry
Uncontrolled Keywords:
KeywordsLanguage
DIFFERENTIAL UPTAKE; F-18-FLUOROETHYL-L-TYROSINEMultiple languages
Radiology, Nuclear Medicine & Medical ImagingMultiple languages
Refereed: Yes
URI: http://kups.ub.uni-koeln.de/id/eprint/20970

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