Hutterer, Markus, Bumes, Elisabeth, Riemenschneider, Markus J., Grosse, Jirka, Hellwig, Dirk ORCID: 0000-0002-3056-0143, Galldiks, Norbert
ORCID: 0000-0002-2485-1796, Langen, Karl-Josef
ORCID: 0000-0003-1101-5075 and Hau, Peter
ORCID: 0000-0003-3894-5053
(2017).
AIDS-Related Central Nervous System Toxoplasmosis With Increased 18F-Fluoroethyl-l-Tyrosine Amino Acid PET Uptake Due to LAT1/2 Expression of Inflammatory Cells.
Clin. Nucl. Med., 42 (12).
S. E506 - 3.
PHILADELPHIA:
LIPPINCOTT WILLIAMS & WILKINS.
ISSN 1536-0229
Abstract
We report the case of a 40-year-old woman with a progressive right-sided hemiparesis. Standard MRI revealed a contrast-enhancing brain lesion within the left basal ganglia. (18)Ffluoroethyl-l-tyrosine (F-18-FET) PET showed a distinct tracer uptake (lesion-to-brain ratio [LBR]: LBRmax = 2.03, LBRmean = 1.68) with a significant larger metabolic lesion volume than contrast-enhancement in MRI, indicating cerebral glioma. Surprisingly, histopathologic analysis demonstrated central nervous system toxoplasmosis with pronounced inflammatory reaction (reactive astrogliosis, microglia activation, macrophage, and T-lymphocyte infiltration), which was associated with strong LAT1/LAT2/CD98 expression. In conclusion, inflammatory brain lesions, such as cerebral toxoplasmosis, represent a potential pitfall of F-18-FET PET mimicking a brain tumor.
Item Type: | Journal Article | ||||||||||||||||||||||||||||||||||||
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URN: | urn:nbn:de:hbz:38-209708 | ||||||||||||||||||||||||||||||||||||
DOI: | 10.1097/RLU.0000000000001873 | ||||||||||||||||||||||||||||||||||||
Journal or Publication Title: | Clin. Nucl. Med. | ||||||||||||||||||||||||||||||||||||
Volume: | 42 | ||||||||||||||||||||||||||||||||||||
Number: | 12 | ||||||||||||||||||||||||||||||||||||
Page Range: | S. E506 - 3 | ||||||||||||||||||||||||||||||||||||
Date: | 2017 | ||||||||||||||||||||||||||||||||||||
Publisher: | LIPPINCOTT WILLIAMS & WILKINS | ||||||||||||||||||||||||||||||||||||
Place of Publication: | PHILADELPHIA | ||||||||||||||||||||||||||||||||||||
ISSN: | 1536-0229 | ||||||||||||||||||||||||||||||||||||
Language: | English | ||||||||||||||||||||||||||||||||||||
Faculty: | Unspecified | ||||||||||||||||||||||||||||||||||||
Divisions: | Unspecified | ||||||||||||||||||||||||||||||||||||
Subjects: | no entry | ||||||||||||||||||||||||||||||||||||
Uncontrolled Keywords: |
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Refereed: | Yes | ||||||||||||||||||||||||||||||||||||
URI: | http://kups.ub.uni-koeln.de/id/eprint/20970 |
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