Universität zu Köln

Verger, Antoine, Filss, Christian P., Lohmann, Philipp ORCID: 0000-0002-5360-046X, Stoffels, Gabriele ORCID: 0000-0001-7114-1941, Sabel, Michael, Wittsack, Hans J., Kops, Elena Rota, Galldiks, Norbert ORCID: 0000-0002-2485-1796, Fink, Gereon R. ORCID: 0000-0002-8230-1856, Shah, Nadim J. and Langen, Karl-Josef ORCID: 0000-0003-1101-5075 (2017). Comparison of F-18-FET PET and perfusion-weighted MRI for glioma grading: a hybrid PET/MR study. Eur. J. Nucl. Med. Mol. Imaging, 44 (13). S. 2257 - 2266. NEW YORK: SPRINGER. ISSN 1619-7089

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Abstract

Purpose Both perfusion-weighted MR imaging (PWI) and O-(2-F-18-fluoroethyl)-L-tyrosine PET (F-18-FET) provide grading information in cerebral gliomas. The aim of this study was to compare the diagnostic value of F-18-FET PET and PWI for tumor grading in a series of patients with newly diagnosed, untreated gliomas using an integrated PET/MR scanner. Methods Seventy-two patients with untreated gliomas [22 low-grade gliomas (LGG), and 50 high-grade gliomas (HGG)] were investigated with F-18-FET PET and PWI using a hybrid PET/MR scanner. After visual inspection of PET and PWI maps (rCBV, rCBF, MTT), volumes of interest (VOIs) with a diameter of 16 mm were centered upon the maximum of abnormality in the tumor area in each modality and the contralateral unaffected hemisphere. Mean and maximum tumor-to-brain ratios (TBRmean, TBRmax) were calculated. In addition, Time-to-Peak (TTP) and slopes of time-activity curves were calculated for F-18-FET PET. Diagnostic accuracies of F-18-FET PET and PWI for differentiating low-grade glioma (LGG) from high-grade glioma (HGG) were evaluated by receiver operating characteristic analyses (area under the curve; AUC). Results The diagnostic accuracy of F-18-FET PET and PWI to discriminate LGG from HGG was similar with highest AUC values for TBRmean and TBRmax of F-18-FET PET uptake (0.80, 0.83) and for TBRmean and TBRmax of rCBV (0.80, 0.81). In case of increased signal in the tumor area with both methods (n = 32), local hot-spots were incongruent in 25 patients (78%) with a mean distance of 10.6 +/- 9.5 mm. Dynamic FET PET and combination of different parameters did not further improve diagnostic accuracy. Conclusions Both F-18-FET PET and PWI discriminate LGG from HGG with similar diagnostic performance. Regional abnormalities in the tumor area are usually not congruent indicating that tumor grading by F-18-FET PET and PWI is based on different pathophysiological phenomena.

Item Type:	Journal Article
Creators:	Creators Email ORCID ORCID Put Code Verger, Antoine UNSPECIFIED UNSPECIFIED UNSPECIFIED Filss, Christian P. UNSPECIFIED UNSPECIFIED UNSPECIFIED Lohmann, Philipp UNSPECIFIED orcid.org/0000-0002-5360-046X UNSPECIFIED Stoffels, Gabriele UNSPECIFIED orcid.org/0000-0001-7114-1941 UNSPECIFIED Sabel, Michael UNSPECIFIED UNSPECIFIED UNSPECIFIED Wittsack, Hans J. UNSPECIFIED UNSPECIFIED UNSPECIFIED Kops, Elena Rota UNSPECIFIED UNSPECIFIED UNSPECIFIED Galldiks, Norbert UNSPECIFIED orcid.org/0000-0002-2485-1796 UNSPECIFIED Fink, Gereon R. UNSPECIFIED orcid.org/0000-0002-8230-1856 UNSPECIFIED Shah, Nadim J. UNSPECIFIED UNSPECIFIED UNSPECIFIED Langen, Karl-Josef UNSPECIFIED orcid.org/0000-0003-1101-5075 UNSPECIFIED
URN:	urn:nbn:de:hbz:38-210108
DOI:	10.1007/s00259-017-3812-3
Journal or Publication Title:	Eur. J. Nucl. Med. Mol. Imaging
Volume:	44
Number:	13
Page Range:	S. 2257 - 2266
Date:	2017
Publisher:	SPRINGER
Place of Publication:	NEW YORK
ISSN:	1619-7089
Language:	English
Faculty:	Unspecified
Divisions:	Unspecified
Subjects:	no entry
Uncontrolled Keywords:	Keywords Language CEREBRAL BLOOD-VOLUME; RESPONSE ASSESSMENT; PREDICTIVE VALUES; BRAIN-TUMORS; FET-PET; CLASSIFICATION; SPECTROSCOPY; BEVACIZUMAB; SPECIFICITY; SENSITIVITY Multiple languages Radiology, Nuclear Medicine & Medical Imaging Multiple languages
Refereed:	Yes
URI:	http://kups.ub.uni-koeln.de/id/eprint/21010