Universität zu Köln

Plaeschke, Rachel N., Cieslik, Edna C., Mueller, Veronika I., Hoffstaedter, Felix, Plachti, Anna, Varikuti, Deepthi P., Goosses, Mareike, Latz, Anne, Caspers, Svenja ORCID: 0000-0001-5083-4669, Jockwitz, Christiane, Moebus, Susanne, Gruber, Oliver, Eickhoff, Claudia R., Reetz, Kathrin, Heller, Julia, Suedmeyer, Martin, Mathys, Christian, Caspers, Julian, Grefkes, Christian ORCID: 0000-0002-1656-720X, Kalenscher, Tobias ORCID: 0000-0002-0358-9020, Langner, Robert ORCID: 0000-0002-3237-001X and Eickhoff, Simon B. ORCID: 0000-0001-6363-2759 (2017). On the Integrity of Functional Brain Networks in Schizophrenia, Parkinson's Disease, and Advanced Age: Evidence from Connectivity-Based Single-Subject Classification. Hum. Brain Mapp., 38 (12). S. 5845 - 5859. HOBOKEN: WILEY. ISSN 1097-0193

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Abstract

Previous whole-brain functional connectivity studies achieved successful classifications of patients and healthy controls but only offered limited specificity as to affected brain systems. Here, we examined whether the connectivity patterns of functional systems affected in schizophrenia (SCZ), Parkinson's disease (PD), or normal aging equally translate into high classification accuracies for these conditions. We compared classification performance between pre-defined networks for each group and, for any given network, between groups. Separate support vector machine classifications of 86 SCZ patients, 80 PD patients, and 95 older adults relative to their matched healthy/young controls, respectively, were performed on functional connectivity in 12 task-based, meta-analytically defined networks using 25 replications of a nested 10-fold cross-validation scheme. Classification performance of the various networks clearly differed between conditions, as those networks that best classified one disease were usually non-informative for the other. For SCZ, but not PD, emotion-processing, empathy, and cognitive action control networks distinguished patients most accurately from controls. For PD, but not SCZ, networks subserving autobiographical or semantic memory, motor execution, and theory-of-mind cognition yielded the best classifications. In contrast, young-old classification was excellent based on all networks and outperformed both clinical classifications. Our pattern-classification approach captured associations between clinical and developmental conditions and functional network integrity with a higher level of specificity than did previous whole-brain analyses. Taken together, our results support resting-state connectivity as a marker of functional dysregulation in specific networks known to be affected by SCZ and PD, while suggesting that aging affects network integrity in a more global way. (C) 2017 Wiley Periodicals, Inc.

Item Type:	Journal Article
Creators:	Creators Email ORCID ORCID Put Code Plaeschke, Rachel N. UNSPECIFIED UNSPECIFIED UNSPECIFIED Cieslik, Edna C. UNSPECIFIED UNSPECIFIED UNSPECIFIED Mueller, Veronika I. UNSPECIFIED UNSPECIFIED UNSPECIFIED Hoffstaedter, Felix UNSPECIFIED UNSPECIFIED UNSPECIFIED Plachti, Anna UNSPECIFIED UNSPECIFIED UNSPECIFIED Varikuti, Deepthi P. UNSPECIFIED UNSPECIFIED UNSPECIFIED Goosses, Mareike UNSPECIFIED UNSPECIFIED UNSPECIFIED Latz, Anne UNSPECIFIED UNSPECIFIED UNSPECIFIED Caspers, Svenja UNSPECIFIED orcid.org/0000-0001-5083-4669 UNSPECIFIED Jockwitz, Christiane UNSPECIFIED UNSPECIFIED UNSPECIFIED Moebus, Susanne UNSPECIFIED UNSPECIFIED UNSPECIFIED Gruber, Oliver UNSPECIFIED UNSPECIFIED UNSPECIFIED Eickhoff, Claudia R. UNSPECIFIED UNSPECIFIED UNSPECIFIED Reetz, Kathrin UNSPECIFIED UNSPECIFIED UNSPECIFIED Heller, Julia UNSPECIFIED UNSPECIFIED UNSPECIFIED Suedmeyer, Martin UNSPECIFIED UNSPECIFIED UNSPECIFIED Mathys, Christian UNSPECIFIED UNSPECIFIED UNSPECIFIED Caspers, Julian UNSPECIFIED UNSPECIFIED UNSPECIFIED Grefkes, Christian UNSPECIFIED orcid.org/0000-0002-1656-720X UNSPECIFIED Kalenscher, Tobias UNSPECIFIED orcid.org/0000-0002-0358-9020 UNSPECIFIED Langner, Robert UNSPECIFIED orcid.org/0000-0002-3237-001X UNSPECIFIED Eickhoff, Simon B. UNSPECIFIED orcid.org/0000-0001-6363-2759 UNSPECIFIED
URN:	urn:nbn:de:hbz:38-210133
DOI:	10.1002/hbm.23763
Journal or Publication Title:	Hum. Brain Mapp.
Volume:	38
Number:	12
Page Range:	S. 5845 - 5859
Date:	2017
Publisher:	WILEY
Place of Publication:	HOBOKEN
ISSN:	1097-0193
Language:	English
Faculty:	Unspecified
Divisions:	Unspecified
Subjects:	no entry
Uncontrolled Keywords:	Keywords Language COGNITIVE IMPAIRMENT; PATTERN-RECOGNITION; ALE METAANALYSIS; WORKING-MEMORY; DOPAMINE; NEUROSCIENCE; ACTIVATION; DIAGNOSIS; DEMENTIA; SUPPORT Multiple languages Neurosciences; Neuroimaging; Radiology, Nuclear Medicine & Medical Imaging Multiple languages
Refereed:	Yes
URI:	http://kups.ub.uni-koeln.de/id/eprint/21013