Universität zu Köln

Fengler, Sophie, Liepelt-Scarfone, Inga, Brockmann, Kathrin, Schaeffer, Eva, Berg, Daniela and Kalbe, Elke (2017). Cognitive Changes in Prodromal Parkinson's Disease: A Review. Mov. Disord., 32 (12). S. 1655 - 1667. HOBOKEN: WILEY. ISSN 1531-8257

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Abstract

Although other nonmotor phenomena representing possible prodromal symptoms of Parkinson's disease have been described in some detail, the occurrence and characteristics of cognitive decline in this early phase of the disease are less well understood. The aim of this review is to summarize the current state of research on cognitive changes in prodromal PD. Only a small number of longitudinal studies have been conducted that examined cognitive function in individuals with a subsequent PD diagnosis. However, when we consider data from at-risk groups, the evidence suggests that cognitive decline may occur in a substantial number of individuals who have the potential for developing PD. In terms of specific cognitive domains, executive function in particular and, less frequently, memory scores are reduced. Prospective longitudinal studies are thus needed to clarify whether cognitive, and specifically executive, decline might be added to the prodromal nonmotor symptom complex that may precede motor manifestations of PD by years and may help to update the risk scores used for early identification of PD. (C) 2017 International Parkinson and Movement Disorder Society

Item Type:	Journal Article
Creators:	Creators Email ORCID ORCID Put Code Fengler, Sophie UNSPECIFIED UNSPECIFIED UNSPECIFIED Liepelt-Scarfone, Inga UNSPECIFIED UNSPECIFIED UNSPECIFIED Brockmann, Kathrin UNSPECIFIED UNSPECIFIED UNSPECIFIED Schaeffer, Eva UNSPECIFIED UNSPECIFIED UNSPECIFIED Berg, Daniela UNSPECIFIED UNSPECIFIED UNSPECIFIED Kalbe, Elke UNSPECIFIED UNSPECIFIED UNSPECIFIED
URN:	urn:nbn:de:hbz:38-210316
DOI:	10.1002/mds.27135
Journal or Publication Title:	Mov. Disord.
Volume:	32
Number:	12
Page Range:	S. 1655 - 1667
Date:	2017
Publisher:	WILEY
Place of Publication:	HOBOKEN
ISSN:	1531-8257
Language:	English
Faculty:	Unspecified
Divisions:	Unspecified
Subjects:	no entry
Uncontrolled Keywords:	Keywords Language SLEEP BEHAVIOR DISORDER; SUBSTANTIA-NIGRA HYPERECHOGENICITY; LEWY BODY DISEASE; ALPHA-SYNUCLEIN; NONMOTOR FEATURES; G2019S MUTATION; NEUROPSYCHOLOGICAL IMPAIRMENT; TRANSCRANIAL SONOGRAPHY; EXECUTIVE FUNCTIONS; GBA MUTATION Multiple languages Clinical Neurology Multiple languages
Refereed:	Yes
URI:	http://kups.ub.uni-koeln.de/id/eprint/21031