Nowosielski, Martha, Galldiks, Norbert ORCID: 0000-0002-2485-1796, Iglseder, Sarah, Kickingereder, Philipp, von Deimling, Andreas ORCID: 0000-0002-5863-540X, Bendszus, Martin, Wick, Wolfgang ORCID: 0000-0002-6171-634X and Sahm, Felix ORCID: 0000-0001-5441-1962 (2017). Diagnostic challenges in meningioma. Neuro-Oncology, 19 (12). S. 1588 - 1599. CARY: OXFORD UNIV PRESS INC. ISSN 1523-5866
Full text not available from this repository.Abstract
Advances in molecular profiling and the application of advanced imaging techniques are currently refreshing diagnostic considerations in meningioma patients. Not only technical refinements but also sophisticated histopathological and molecular studies have the potential to overcome some of the challenges during meningioma management. Exact tumor delineation, assessment of tumor growth, and pathophysiological parameters were recently addressed by advanced MRI and PET. In the field of neuropathology, high-throughput sequencing and DNA methylation analysis of meningioma tissue has greatly advanced the knowledge of molecular aberrations in meningioma patients. These techniques allow for more reliable prediction of the biological behavior and clinical course of meningiomas and subsequently have the potential to guide individualized meningioma therapy. However, higher costs and longer duration of full molecular work-up compared with histological assessment may delay the implementation into clinical routine. This review highlights the diagnostic challenges of meningiomas from both the neuroimaging as well as the neuropathological side and presents the latest scientific achievements and studies potentially helping in overcoming these challenges. It complements the recently proposed European Association of Neuro-Oncology guidelines on treatment and diagnosis of meningiomas by integrating data on nonstandard imaging and molecular assessments most likely impacting the future.
Item Type: | Journal Article | ||||||||||||||||||||||||||||||||||||
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URN: | urn:nbn:de:hbz:38-210375 | ||||||||||||||||||||||||||||||||||||
DOI: | 10.1093/neuonc/nox101 | ||||||||||||||||||||||||||||||||||||
Journal or Publication Title: | Neuro-Oncology | ||||||||||||||||||||||||||||||||||||
Volume: | 19 | ||||||||||||||||||||||||||||||||||||
Number: | 12 | ||||||||||||||||||||||||||||||||||||
Page Range: | S. 1588 - 1599 | ||||||||||||||||||||||||||||||||||||
Date: | 2017 | ||||||||||||||||||||||||||||||||||||
Publisher: | OXFORD UNIV PRESS INC | ||||||||||||||||||||||||||||||||||||
Place of Publication: | CARY | ||||||||||||||||||||||||||||||||||||
ISSN: | 1523-5866 | ||||||||||||||||||||||||||||||||||||
Language: | English | ||||||||||||||||||||||||||||||||||||
Faculty: | Unspecified | ||||||||||||||||||||||||||||||||||||
Divisions: | Unspecified | ||||||||||||||||||||||||||||||||||||
Subjects: | no entry | ||||||||||||||||||||||||||||||||||||
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Refereed: | Yes | ||||||||||||||||||||||||||||||||||||
URI: | http://kups.ub.uni-koeln.de/id/eprint/21037 |
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