Universität zu Köln

Hammes, Jochen, Leuwer, Isabel, Bischof, Gerard N., Drzezga, Alexander and van Eimeren, Thilo (2017). Multimodal correlation of dynamic [F-18]-AV-1451 perfusion PET and neuronal hypometabolism in [F-18]-FDG PET. Eur. J. Nucl. Med. Mol. Imaging, 44 (13). S. 2249 - 2257. NEW YORK: SPRINGER. ISSN 1619-7089

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Abstract

Purpose Cerebral glucose metabolism measured with [18F]-FDG PET is a well established marker of neuronal dysfunction in neurodegeneration. The tau-protein tracer [18F]-AV-1451 PET is currently under evaluation and shows promising results. Here, we assess the feasibility of early perfusion imaging with AV-1451 as a substite for FDG PET in assessing neuronal injury. Methods Twenty patients with suspected neurodegeneration underwent FDG and early phase AV-1451 PET imaging. Ten one-minute timeframes were acquired after application of 200 MBq AV-1451. FDG images were acquired on a different date according to clinical protocol. Early AV-1451 timeframes were coregistered to individual FDG-scans and spatially normalized. Voxel-wise intermodal correlations were calculated on within-subject level for every possible time window. The window with highest pooled correlation was considered optimal. Z-transformed deviation maps (ZMs) were created from both FDG and early AV-1451 images, comparing against FDG images of healthy controls. Results Regional patterns and extent of perfusion deficits were highly comparable to metabolic deficits. Best results were observed in a time window from 60 to 360 s (r = 0.86). Correlation strength ranged from r = 0.96 (subcortical gray matter) to 0.83 (frontal lobe) in regional analysis. ZMs of early AV-1451 and FDG images were highly similar. Conclusions Perfusion imaging with AV-1451 is a valid biomarker for assessment of neuronal dysfunction in neurodegenerative diseases. Radiation exposure and complexity of the diagnostic workup could be reduced significantly by routine acquisition of early AV-1451 images, sparing additional FDG PET.

Item Type:	Journal Article
Creators:	Creators Email ORCID ORCID Put Code Hammes, Jochen UNSPECIFIED UNSPECIFIED UNSPECIFIED Leuwer, Isabel UNSPECIFIED UNSPECIFIED UNSPECIFIED Bischof, Gerard N. UNSPECIFIED UNSPECIFIED UNSPECIFIED Drzezga, Alexander UNSPECIFIED UNSPECIFIED UNSPECIFIED van Eimeren, Thilo UNSPECIFIED UNSPECIFIED UNSPECIFIED
URN:	urn:nbn:de:hbz:38-210529
DOI:	10.1007/s00259-017-3840-z
Journal or Publication Title:	Eur. J. Nucl. Med. Mol. Imaging
Volume:	44
Number:	13
Page Range:	S. 2249 - 2257
Date:	2017
Publisher:	SPRINGER
Place of Publication:	NEW YORK
ISSN:	1619-7089
Language:	English
Faculty:	Unspecified
Divisions:	Unspecified
Subjects:	no entry
Uncontrolled Keywords:	Keywords Language PROGRESSIVE SUPRANUCLEAR PALSY; POSITRON-EMISSION-TOMOGRAPHY; F-18-FLORBETAPIR AV-45/AMYVID PET; ALZHEIMERS-DISEASE; TAU-PET; FRONTOTEMPORAL DEMENTIA; GLUCOSE-METABOLISM; IMAGING AGENT; BRAIN; F-18-AV-1451 Multiple languages Radiology, Nuclear Medicine & Medical Imaging Multiple languages
Refereed:	Yes
URI:	http://kups.ub.uni-koeln.de/id/eprint/21052