Universität zu Köln

Baessler, Bettina ORCID: 0000-0002-3244-3864, Schaarschmidt, Frank, Treutlein, Melanie, Stehning, Christian, Schnackenburg, Bernhard, Michels, Guido, Maintz, David and Bunck, Alexander C. (2017). Re-evaluation of a novel approach for quantitative myocardial oedema detection by analysing tissue inhomogeneity in acute myocarditis using T2-mapping. Eur. Radiol., 27 (12). S. 5169 - 5179. NEW YORK: SPRINGER. ISSN 1432-1084

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Abstract

To re-evaluate a recently suggested approach of quantifying myocardial oedema and increased tissue inhomogeneity in myocarditis by T2-mapping. Cardiac magnetic resonance data of 99 patients with myocarditis were retrospectively analysed. Thirthy healthy volunteers served as controls. T2-mapping data were acquired at 1.5 T using a gradient-spin-echo T2-mapping sequence. T2-maps were segmented according to the 16-segments AHA-model. Segmental T2-values, segmental pixel-standard deviation (SD) and the derived parameters maxT2, maxSD and madSD were analysed and compared to the established Lake Louise criteria (LLC). A re-estimation of logistic regression models revealed that all models containing an SD-parameter were superior to any model containing global myocardial T2. Using a combined cut-off of 1.8 ms for madSD + 68 ms for maxT2 resulted in a diagnostic sensitivity of 75% and specificity of 80% and showed a similar diagnostic performance compared to LLC in receiver-operating-curve analyses. Combining madSD, maxT2 and late gadolinium enhancement (LGE) in a model resulted in a superior diagnostic performance compared to LLC (sensitivity 93%, specificity 83%). The results show that the novel T2-mapping-derived parameters exhibit an additional diagnostic value over LGE with the inherent potential to overcome the current limitations of T2-mapping.

Item Type:	Journal Article
Creators:	Creators Email ORCID ORCID Put Code Baessler, Bettina UNSPECIFIED orcid.org/0000-0002-3244-3864 UNSPECIFIED Schaarschmidt, Frank UNSPECIFIED UNSPECIFIED UNSPECIFIED Treutlein, Melanie UNSPECIFIED UNSPECIFIED UNSPECIFIED Stehning, Christian UNSPECIFIED UNSPECIFIED UNSPECIFIED Schnackenburg, Bernhard UNSPECIFIED UNSPECIFIED UNSPECIFIED Michels, Guido UNSPECIFIED UNSPECIFIED UNSPECIFIED Maintz, David UNSPECIFIED UNSPECIFIED UNSPECIFIED Bunck, Alexander C. UNSPECIFIED UNSPECIFIED UNSPECIFIED
URN:	urn:nbn:de:hbz:38-210585
DOI:	10.1007/s00330-017-4894-9
Journal or Publication Title:	Eur. Radiol.
Volume:	27
Number:	12
Page Range:	S. 5169 - 5179
Date:	2017
Publisher:	SPRINGER
Place of Publication:	NEW YORK
ISSN:	1432-1084
Language:	English
Faculty:	Unspecified
Divisions:	Unspecified
Subjects:	no entry
Uncontrolled Keywords:	Keywords Language CARDIOVASCULAR MAGNETIC-RESONANCE; ENDOMYOCARDIAL BIOPSY; DIAGNOSIS; MANAGEMENT; THERAPY; MRI; CMR; T1 Multiple languages Radiology, Nuclear Medicine & Medical Imaging Multiple languages
Refereed:	Yes
URI:	http://kups.ub.uni-koeln.de/id/eprint/21058