Universität zu Köln

Castillo Gomez, J. D., Hagenbach, A., Gerling-Driessen, U. I. M., Koksch, B., Beindorff, N., Brenner, W. and Abram, U. (2017). Thiourea derivatives as chelating agents for bioconjugation of rhenium and technetium. Dalton Trans., 46 (42). S. 14602 - 14612. CAMBRIDGE: ROYAL SOC CHEMISTRY. ISSN 1477-9234

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Abstract

Potential tetradentate thiocarbamoylbenzamidine derivatives H4L have been synthesized from the corresponding benzimidoyl chlorides and triglycine. They are suitable chelating agents for the oxidotechnetium(V) and oxidorhenium(V) cores and form stable, neutral [MO(HL)] complexes with an equatorial SN3 coordination sphere and an additional, uncoordinated carboxylic group, which can be used for bioconjugation. Representatives of the rhenium and Tc-99 products have been isolated and analyzed with spectroscopic methods and X-ray diffraction. Bioconjugates of these complexes with angiotensin-II have been synthesized and structurally characterized. Analogous (99)mTc complexes have been produced and tested in vitro and in vivo. The experiments confirm a considerable stability for the [(99)mTc(HL)] product as well as for its bioconjugate and recommend this class of compounds for further bioconjugation studies towards clinical applications.

Item Type:	Journal Article
Creators:	Creators Email ORCID ORCID Put Code Castillo Gomez, J. D. UNSPECIFIED UNSPECIFIED UNSPECIFIED Hagenbach, A. UNSPECIFIED UNSPECIFIED UNSPECIFIED Gerling-Driessen, U. I. M. UNSPECIFIED UNSPECIFIED UNSPECIFIED Koksch, B. UNSPECIFIED UNSPECIFIED UNSPECIFIED Beindorff, N. UNSPECIFIED UNSPECIFIED UNSPECIFIED Brenner, W. UNSPECIFIED UNSPECIFIED UNSPECIFIED Abram, U. UNSPECIFIED UNSPECIFIED UNSPECIFIED
URN:	urn:nbn:de:hbz:38-211275
DOI:	10.1039/c7dt01834g
Journal or Publication Title:	Dalton Trans.
Volume:	46
Number:	42
Page Range:	S. 14602 - 14612
Date:	2017
Publisher:	ROYAL SOC CHEMISTRY
Place of Publication:	CAMBRIDGE
ISSN:	1477-9234
Language:	English
Faculty:	Unspecified
Divisions:	Unspecified
Subjects:	no entry
Uncontrolled Keywords:	Keywords Language COORDINATION CHEMISTRY; COMPLEXES; PEPTIDE; LIGAND; BENZAMIDINES; RE Multiple languages Chemistry, Inorganic & Nuclear Multiple languages
Refereed:	Yes
URI:	http://kups.ub.uni-koeln.de/id/eprint/21127