Universität zu Köln

Villa, Mara ORCID: 0000-0003-2543-027X and Laessig, Michael (2017). Fitness cost of reassortment in human influenza. PLoS Pathog., 13 (11). SAN FRANCISCO: PUBLIC LIBRARY SCIENCE. ISSN 1553-7374

Full text not available from this repository.

Abstract

Reassortment, which is the exchange of genome sequence between viruses co-infecting a host cell, plays an important role in the evolution of segmented viruses. In the human influenza virus, reassortment happens most frequently between co-existing variants within the same lineage. This process breaks genetic linkage and fitness correlations between viral genome segments, but the resulting net effect on viral fitness has remained unclear. In this paper, we determine rate and average selective effect of reassortment processes in the human influenza lineage A/H3N2. For the surface proteins hemagglutinin and neuraminidase, reassortant variants with a mean distance of at least 3 nucleotides to their parent strains get established at a rate of about 10(-2) in units of the neutral point mutation rate. Our inference is based on a new method to map reassortment events from joint genealogies of multiple genome segments, which is tested by extensive simulations. We show that intra-lineage reassortment processes are, on average, under substantial negative selection that increases in strength with increasing sequence distance between the parent strains. The deleterious effects of reassortment manifest themselves in two ways: there are fewer reassortment events than expected from a null model of neutral reassortment, and reassortant strains have fewer descendants than their non-reassortant counterparts. Our results suggest that influenza evolves under ubiquitous epistasis across proteins, which produces fitness barriers against reassortment even between co-circulating strains within one lineage.

Item Type:	Journal Article
Creators:	Creators Email ORCID ORCID Put Code Villa, Mara UNSPECIFIED orcid.org/0000-0003-2543-027X UNSPECIFIED Laessig, Michael UNSPECIFIED UNSPECIFIED UNSPECIFIED
URN:	urn:nbn:de:hbz:38-211898
DOI:	10.1371/journal.ppat.1006685
Journal or Publication Title:	PLoS Pathog.
Volume:	13
Number:	11
Date:	2017
Publisher:	PUBLIC LIBRARY SCIENCE
Place of Publication:	SAN FRANCISCO
ISSN:	1553-7374
Language:	English
Faculty:	Faculty of Mathematics and Natural Sciences
Divisions:	Faculty of Mathematics and Natural Sciences > Department of Physics > Institut für Biologische Physik
Subjects:	no entry
Uncontrolled Keywords:	Keywords Language A H3N2 VIRUSES; PHYLOGENETIC ANALYSIS; GENETIC EVOLUTION; A(H3N2) VIRUSES; AVIAN H5N1; NEURAMINIDASE; ANTIBODY; COMPATIBILITY; REPLICATION; LINEAGES Multiple languages Microbiology; Parasitology; Virology Multiple languages
Refereed:	Yes
URI:	http://kups.ub.uni-koeln.de/id/eprint/21189