Koenigsmann, Tatiana, Turetzek, Natascha, Pechmann, Matthias and Prpic, Nikola-Michael (2017). Expression and function of the zinc finger transcription factor Sp6-9 in the spider Parasteatoda tepidariorum. Dev. Genes Evol., 227 (6). S. 389 - 401. NEW YORK: SPRINGER. ISSN 1432-041X
Full text not available from this repository.Abstract
Zinc finger transcription factors of the Sp6-9 group are evolutionarily conserved in all metazoans and have important functions in, e.g., limb formation and heart development. The function of Sp6-9-related genes has been studied in a number of vertebrates and invertebrates, but data from chelicerates (spiders and allies) was lacking so far. We have isolated the ortholog of Sp6-9 from the common house spider Parasteatoda tepidariorum and the cellar spider Pholcus phalangioides. We show that the Sp6-9 gene in these spider species is expressed in the developing appendages thus suggesting a conserved role in limb formation. Indeed, RNAi with Sp6-9 in P. tepidariorum leads not only to strong limb defects, but also to the loss of body segments and head defects in more strongly affected animals. Together with a new expression domain in the early embryo, these data suggest that Sp6-9 has a dual role P. tepidariorum. The early role in head and body segment formation is not known from other arthropods, but the role in limb formation is evolutionarily highly conserved.
Item Type: | Journal Article | ||||||||||||||||||||
Creators: |
|
||||||||||||||||||||
URN: | urn:nbn:de:hbz:38-211967 | ||||||||||||||||||||
DOI: | 10.1007/s00427-017-0595-2 | ||||||||||||||||||||
Journal or Publication Title: | Dev. Genes Evol. | ||||||||||||||||||||
Volume: | 227 | ||||||||||||||||||||
Number: | 6 | ||||||||||||||||||||
Page Range: | S. 389 - 401 | ||||||||||||||||||||
Date: | 2017 | ||||||||||||||||||||
Publisher: | SPRINGER | ||||||||||||||||||||
Place of Publication: | NEW YORK | ||||||||||||||||||||
ISSN: | 1432-041X | ||||||||||||||||||||
Language: | English | ||||||||||||||||||||
Faculty: | Unspecified | ||||||||||||||||||||
Divisions: | Unspecified | ||||||||||||||||||||
Subjects: | no entry | ||||||||||||||||||||
Uncontrolled Keywords: |
|
||||||||||||||||||||
Refereed: | Yes | ||||||||||||||||||||
URI: | http://kups.ub.uni-koeln.de/id/eprint/21196 |
Downloads
Downloads per month over past year
Altmetric
Export
Actions (login required)
View Item |