Wurzinger, Bernhard ORCID: 0000-0002-9302-2967, Mair, Andrea ORCID: 0000-0002-2492-4318, Fischer-Schrader, Katrin ORCID: 0000-0003-4532-8918, Nukarinen, Ella ORCID: 0000-0002-7092-2305, Roustan, Valentin, Weckwerth, Wolfram ORCID: 0000-0002-9719-6358 and Teige, Markus ORCID: 0000-0001-7204-1379 (2017). Redox state-dependent modulation of plant SnRK1 kinase activity differs from AMPK regulation in animals. FEBS Lett., 591 (21). S. 3625 - 3637. HOBOKEN: WILEY. ISSN 1873-3468

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Abstract

The evolutionarily highly conserved SNF1-related protein kinase (SnRK1) protein kinase is a metabolic master regulator in plants, balancing the critical energy consumption between growth- and stress response-related metabolic pathways. While the regulation of the mammalian [AMP-activated protein kinase (AMPK)] and yeast (SNF1) orthologues of SnRK1 is well-characterised, the regulation of SnRK1 kinase activity in plants is still an open question. Here we report that the activity and T-loop phosphorylation of AKIN10, the kinase subunit of the SnRK1 complex, is regulated by the redox status. Although this regulation is dependent on a conserved cysteine residue, the underlying mechanism is different to the redox regulation of animal AMPK and has functional implications for the regulation of the kinase complex in plants under stress conditions.

Item Type: Journal Article
Creators:
CreatorsEmailORCIDORCID Put Code
Wurzinger, BernhardUNSPECIFIEDorcid.org/0000-0002-9302-2967UNSPECIFIED
Mair, AndreaUNSPECIFIEDorcid.org/0000-0002-2492-4318UNSPECIFIED
Fischer-Schrader, KatrinUNSPECIFIEDorcid.org/0000-0003-4532-8918UNSPECIFIED
Nukarinen, EllaUNSPECIFIEDorcid.org/0000-0002-7092-2305UNSPECIFIED
Roustan, ValentinUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Weckwerth, WolframUNSPECIFIEDorcid.org/0000-0002-9719-6358UNSPECIFIED
Teige, MarkusUNSPECIFIEDorcid.org/0000-0001-7204-1379UNSPECIFIED
URN: urn:nbn:de:hbz:38-212544
DOI: 10.1002/1873-3468.12852
Journal or Publication Title: FEBS Lett.
Volume: 591
Number: 21
Page Range: S. 3625 - 3637
Date: 2017
Publisher: WILEY
Place of Publication: HOBOKEN
ISSN: 1873-3468
Language: English
Faculty: Unspecified
Divisions: Unspecified
Subjects: no entry
Uncontrolled Keywords:
KeywordsLanguage
ACTIVATED PROTEIN-KINASE; ARABIDOPSIS-THALIANA; QUANTITATIVE PHOSPHOPROTEOMICS; ENERGY DEPRIVATION; NITRATE REDUCTASE; STRUCTURAL BASIS; MAMMALIAN AMPK; YEAST; PHOSPHORYLATION; INHIBITIONMultiple languages
Biochemistry & Molecular Biology; Biophysics; Cell BiologyMultiple languages
Refereed: Yes
URI: http://kups.ub.uni-koeln.de/id/eprint/21254

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