Abken, Hinrich (2017). Driving CARs on the Highway to Solid Cancer: Some Considerations on the Adoptive Therapy with CAR T Cells. Hum. Gene Ther., 28 (11). S. 1047 - 1061. NEW ROCHELLE: MARY ANN LIEBERT, INC. ISSN 1557-7422
Full text not available from this repository.Abstract
Adoptive therapy with chimeric antigen receptor (CAR) redirected T cells achieved lasting remissions in hematologic malignancies, even in terminal stages of the disease. Exploring CAR T cell therapy in the treatment of solid tumors has just begun, balancing efficacy versus toxicity in early phase trials. In contrast to leukemia/lymphoma, solid tumors display a tremendously variable biology demanding different strategies to make a T cell attack successful in the long term. This article summarizes current developments, discusses the hurdles, and considers some modifications to improve the CAR T cell therapy in the treatment of solid tumors.
Item Type: | Journal Article | ||||||||
Creators: |
|
||||||||
URN: | urn:nbn:de:hbz:38-212838 | ||||||||
DOI: | 10.1089/hum.2017.115 | ||||||||
Journal or Publication Title: | Hum. Gene Ther. | ||||||||
Volume: | 28 | ||||||||
Number: | 11 | ||||||||
Page Range: | S. 1047 - 1061 | ||||||||
Date: | 2017 | ||||||||
Publisher: | MARY ANN LIEBERT, INC | ||||||||
Place of Publication: | NEW ROCHELLE | ||||||||
ISSN: | 1557-7422 | ||||||||
Language: | English | ||||||||
Faculty: | Unspecified | ||||||||
Divisions: | Unspecified | ||||||||
Subjects: | no entry | ||||||||
Uncontrolled Keywords: |
|
||||||||
Refereed: | Yes | ||||||||
URI: | http://kups.ub.uni-koeln.de/id/eprint/21283 |
Downloads
Downloads per month over past year
Altmetric
Export
Actions (login required)
View Item |