Universität zu Köln

Tan, Linette Liqi ORCID: 0000-0002-8684-4698, Pelzer, Patric, Heinl, Celine ORCID: 0000-0003-3369-1939, Tang, Wannan, Gangadharan, Vijayan, Flor, Herta ORCID: 0000-0003-4809-5398, Sprengel, Rolf, Kuner, Thomas ORCID: 0000-0003-1896-9031 and Kuner, Rohini (2017). A pathway from midcingulate cortex to posterior insula gates nociceptive hypersensitivity. Nat. Neurosci., 20 (11). S. 1591 - 1605. NEW YORK: NATURE PUBLISHING GROUP. ISSN 1546-1726

Full text not available from this repository.

Abstract

The identity of cortical circuits mediating nociception and pain is largely unclear. The cingulate cortex is consistently activated during pain, but the functional specificity of cingulate divisions, the roles at distinct temporal phases of central plasticity and the underlying circuitry are unknown. Here we show in mice that the midcingulate division of the cingulate cortex (MCC) does not mediate acute pain sensation and pain affect, but gates sensory hypersensitivity by acting in a wide cortical and subcortical network. Within this complex network, we identified an afferent MCC-posterior insula pathway that can induce and maintain nociceptive hypersensitivity in the absence of conditioned peripheral noxious drive. This facilitation of nociception is brought about by recruitment of descendingserotonergic facilitatory projections to the spinal cord. These results have implications for our understanding of neuronal mechanisms facilitating the transition from acute to long-lasting pain.

Item Type:	Journal Article
Creators:	Creators Email ORCID ORCID Put Code Tan, Linette Liqi UNSPECIFIED orcid.org/0000-0002-8684-4698 UNSPECIFIED Pelzer, Patric UNSPECIFIED UNSPECIFIED UNSPECIFIED Heinl, Celine UNSPECIFIED orcid.org/0000-0003-3369-1939 UNSPECIFIED Tang, Wannan UNSPECIFIED UNSPECIFIED UNSPECIFIED Gangadharan, Vijayan UNSPECIFIED UNSPECIFIED UNSPECIFIED Flor, Herta UNSPECIFIED orcid.org/0000-0003-4809-5398 UNSPECIFIED Sprengel, Rolf UNSPECIFIED UNSPECIFIED UNSPECIFIED Kuner, Thomas UNSPECIFIED orcid.org/0000-0003-1896-9031 UNSPECIFIED Kuner, Rohini UNSPECIFIED UNSPECIFIED UNSPECIFIED
URN:	urn:nbn:de:hbz:38-212980
DOI:	10.1038/nn.4645
Journal or Publication Title:	Nat. Neurosci.
Volume:	20
Number:	11
Page Range:	S. 1591 - 1605
Date:	2017
Publisher:	NATURE PUBLISHING GROUP
Place of Publication:	NEW YORK
ISSN:	1546-1726
Language:	English
Faculty:	Unspecified
Divisions:	Unspecified
Subjects:	no entry
Uncontrolled Keywords:	Keywords Language ANTERIOR CINGULATE CORTEX; NEUROPATHIC PAIN; ACTIVATION; CIRCUITS; NEURONS; SENSITIZATION; ANTICIPATION; MODULATION; EXPRESSION; DISEASE Multiple languages Neurosciences Multiple languages
Refereed:	Yes
URI:	http://kups.ub.uni-koeln.de/id/eprint/21298