Universität zu Köln

Orban, Ester, Arendt, Marina, Hennig, Frauke, Lucht, Sarah, Eisele, Lewin, Jakobs, Hermann, Duerig, Jan, Hoffmann, Barbara, Joeckel, Karl-Heinz and Moebus, Susanne (2017). Is long-term particulate matter and nitrogen dioxide air pollution associated with incident monoclonal gammopathy of undetermined significance (MGUS)? An analysis of the Heinz Nixdorf Recall study. Environ. Int., 108. S. 237 - 246. OXFORD: PERGAMON-ELSEVIER SCIENCE LTD. ISSN 1873-6750

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Abstract

Background: Exposure to air pollution activates the innate immune system and influences the adaptive immune system in experimental settings. We investigated the association of residential long-term exposure to particulate matter (PM) and NO2 air pollution with monoclonal gammopathy of undetermined significance (MGUS) as a marker of adaptive immune system activation. Methods: We used data from the baseline (2000-2003), 5-year (2006-2008) and 10-year (2011-2015) followup examinations of the German Heinz Nixdorf Recall cohort study of 4814 participants (45-75 years). Residential exposure to PM size fractions and NO2 was estimated by land-use regression (ESCAPE-LUR, annual mean 2008/2009) and dispersion chemistry transport models (EURAD-CTM, 3-year mean at baseline). We used logistic regression to estimate the effects of air pollutants on incident MGUS, adjusting for age, sex, education, smoking status, physical activity, and BMI. As a non-linear approach, we looked at quartiles (2-4) of the air pollutants in comparison to quartile 1. Results: Of the 3949 participants with complete data, 100 developed MGUS during the 10-year follow-up. In the main model, only PMcoarse was associated with incident MGUS (OR per IQR (1.9 mu g/m(3)): 1.32, 95% CI 1.04-1.67). We further found positive associations between PM size fractions estimated by ESCAPE-LUR and incident MGUS by quartiles of exposure (OR Q4 vs Q1: PM2.5 2.03 (1.08-3.80); PM10 1.97 (1.05-3.67); PMcoarse 1.98 (1.09-3.60)). Conclusions: Our results indicate that an association between long-term exposure to PM and MGUS may exist. Further epidemiologic studies are needed to corroborate this possible link.

Item Type:	Journal Article
Creators:	Creators Email ORCID ORCID Put Code Orban, Ester UNSPECIFIED UNSPECIFIED UNSPECIFIED Arendt, Marina UNSPECIFIED UNSPECIFIED UNSPECIFIED Hennig, Frauke UNSPECIFIED UNSPECIFIED UNSPECIFIED Lucht, Sarah UNSPECIFIED UNSPECIFIED UNSPECIFIED Eisele, Lewin UNSPECIFIED UNSPECIFIED UNSPECIFIED Jakobs, Hermann UNSPECIFIED UNSPECIFIED UNSPECIFIED Duerig, Jan UNSPECIFIED UNSPECIFIED UNSPECIFIED Hoffmann, Barbara UNSPECIFIED UNSPECIFIED UNSPECIFIED Joeckel, Karl-Heinz UNSPECIFIED UNSPECIFIED UNSPECIFIED Moebus, Susanne UNSPECIFIED UNSPECIFIED UNSPECIFIED
URN:	urn:nbn:de:hbz:38-213170
DOI:	10.1016/j.envint.2017.08.007
Journal or Publication Title:	Environ. Int.
Volume:	108
Page Range:	S. 237 - 246
Date:	2017
Publisher:	PERGAMON-ELSEVIER SCIENCE LTD
Place of Publication:	OXFORD
ISSN:	1873-6750
Language:	English
Faculty:	Unspecified
Divisions:	Unspecified
Subjects:	no entry
Uncontrolled Keywords:	Keywords Language MULTIPLE-MYELOMA; INFLAMMATORY RESPONSE; MYOCARDIAL-INFARCTION; BLOOD MARKERS; RISK; EXPOSURE; ATHEROSCLEROSIS; PREVALENCE; AUTOIMMUNE; DIAGNOSIS Multiple languages Environmental Sciences Multiple languages
Refereed:	Yes
URI:	http://kups.ub.uni-koeln.de/id/eprint/21317