Hellings, P. W., Klimek, L., Cingi, C., Agache, I., Akdis, C., Bachert, C., Bousquet, J., Demoly, P., Gevaert, P., Hox, V., Hupin, C., Kalogjera, L., Manole, F., Moesges, R., Mullol, J., Muluk, N. B., Muraro, A., Papadopoulos, N., Pawankar, R., Rondon, C., Rundenko, M., Seys, S. F., Toskala, E., Van Gerven, L., Zhang, L., Zhang, N. and Fokkens, W. J. (2017). Non-allergic rhinitis: Position paper of the European Academy of Allergy and Clinical Immunology. Allergy, 72 (11). S. 1657 - 1666. HOBOKEN: WILEY. ISSN 1398-9995

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Abstract

This EAACI position paper aims at providing a state-of-the-art overview on nonallergic rhinitis (NAR). A significant number of patients suffering from persistent rhinitis are defined as nonallergic noninfectious rhinitis (NANIR) patients, often denominated in short as having NAR. NAR is defined as a symptomatic inflammation of the nasal mucosa with the presence of a minimum of two nasal symptoms such as nasal obstruction, rhinorrhea, sneezing, and/or itchy nose, without clinical evidence of endonasal infection and without systemic signs of sensitization to inhalant allergens. Symptoms of NAR may have a wide range of severity and be either continuously present and/or induced by exposure to unspecific triggers, also called nasal hyperresponsiveness (NHR). NHR represents a clinical feature of both AR and NAR patients. NAR involves different subgroups: drug-induced rhinitis, (nonallergic) occupational rhinitis, hormonal rhinitis (including pregnancy rhinitis), gustatory rhinitis, senile rhinitis, and idiopathic rhinitis (IR). NAR should be distinguished from those rhinitis patients with an allergic reaction confined to the nasal mucosa, also called entopy or local allergic rhinitis (LAR). We here provide an overview of the current consensus on phenotypes of NAR, recommendations for diagnosis, a treatment algorithm, and defining the unmet needs in this neglected area of research.

Item Type: Journal Article
Creators:
CreatorsEmailORCIDORCID Put Code
Hellings, P. W.UNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Klimek, L.UNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Cingi, C.UNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Agache, I.UNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Akdis, C.UNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Bachert, C.UNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Bousquet, J.UNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Demoly, P.UNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Gevaert, P.UNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Hox, V.UNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Hupin, C.UNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Kalogjera, L.UNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Manole, F.UNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Moesges, R.UNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Mullol, J.UNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Muluk, N. B.UNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Muraro, A.UNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Papadopoulos, N.UNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Pawankar, R.UNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Rondon, C.UNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Rundenko, M.UNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Seys, S. F.UNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Toskala, E.UNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Van Gerven, L.UNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Zhang, L.UNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Zhang, N.UNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Fokkens, W. J.UNSPECIFIEDUNSPECIFIEDUNSPECIFIED
URN: urn:nbn:de:hbz:38-213207
DOI: 10.1111/all.13200
Journal or Publication Title: Allergy
Volume: 72
Number: 11
Page Range: S. 1657 - 1666
Date: 2017
Publisher: WILEY
Place of Publication: HOBOKEN
ISSN: 1398-9995
Language: English
Faculty: Unspecified
Divisions: Unspecified
Subjects: no entry
Uncontrolled Keywords:
KeywordsLanguage
REDUCES NASAL HYPERREACTIVITY; COLD DRY AIR; VASOMOTOR RHINITIS; DOUBLE-BLIND; ASPIRIN DESENSITIZATION; CHRONIC RHINOSINUSITIS; INTRANASAL CAPSAICIN; IDIOPATHIC RHINITIS; MIXED RHINITIS; PREVALENCEMultiple languages
Allergy; ImmunologyMultiple languages
Refereed: Yes
URI: http://kups.ub.uni-koeln.de/id/eprint/21320

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