Universität zu Köln

Liefers, Bart, Venhuizen, Freerk G., Schreur, Vivian, van Ginneken, Bram, Hoyng, Carel, Fauser, Sascha, Theelen, Thomas and Sanchez, Clara I. (2017). Automatic detection of the foveal center in optical coherence tomography. Biomed. Opt. Express, 8 (11). S. 5160 - 5179. WASHINGTON: OPTICAL SOC AMER. ISSN 2156-7085

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Abstract

We propose a method for automatic detection of the foveal center in optical coherence tomography (OCT). The method is based on a pixel-wise classification of all pixels in an OCT volume using a fully convolutional neural network (CNN) with dilated convolution filters. The CNN-architecture contains anisotropic dilated filters and a shortcut connection and has been trained using a dynamic training procedure where the network identifies its own relevant training samples. The performance of the proposed method is evaluated on a data set of 400 OCT scans of patients affected by age-related macular degeneration (AMD) at different severity levels. For 391 scans (97 : 75%) the method identified the foveal center with a distance to a human reference less than 750 mu m, with a mean (+/- SD) distance of 71 mu m +/- 107 mu m. Two independent observers also annotated the foveal center, with a mean distance to the reference of 57 mu m +/- 84 mu m and 56 mu m +/- 80 mu m, respectively. Furthermore, we evaluate variations to the proposed network architecture and training procedure, providing insight in the characteristics that led to the demonstrated performance of the proposed method. (C) 2017 Optical Society of America.

Item Type:	Journal Article
Creators:	Creators Email ORCID ORCID Put Code Liefers, Bart UNSPECIFIED UNSPECIFIED UNSPECIFIED Venhuizen, Freerk G. UNSPECIFIED UNSPECIFIED UNSPECIFIED Schreur, Vivian UNSPECIFIED UNSPECIFIED UNSPECIFIED van Ginneken, Bram UNSPECIFIED UNSPECIFIED UNSPECIFIED Hoyng, Carel UNSPECIFIED UNSPECIFIED UNSPECIFIED Fauser, Sascha UNSPECIFIED UNSPECIFIED UNSPECIFIED Theelen, Thomas UNSPECIFIED UNSPECIFIED UNSPECIFIED Sanchez, Clara I. UNSPECIFIED UNSPECIFIED UNSPECIFIED
URN:	urn:nbn:de:hbz:38-213321
Journal or Publication Title:	Biomed. Opt. Express
Volume:	8
Number:	11
Page Range:	S. 5160 - 5179
Date:	2017
Publisher:	OPTICAL SOC AMER
Place of Publication:	WASHINGTON
ISSN:	2156-7085
Language:	English
Faculty:	Unspecified
Divisions:	Unspecified
Subjects:	no entry
Uncontrolled Keywords:	Keywords Language VISUAL-ACUITY; RETINAL LAYER; MACULAR DEGENERATION; FLUID SEGMENTATION; OCT IMAGES; THICKNESS; EYES; CLASSIFICATION; HEALTHY; EDEMA Multiple languages Biochemical Research Methods; Optics; Radiology, Nuclear Medicine & Medical Imaging Multiple languages
Refereed:	Yes
URI:	http://kups.ub.uni-koeln.de/id/eprint/21332