Universität zu Köln

Ryczko, Dimitri ORCID: 0000-0003-3948-7728, Graetsch, Swantje, Schlager, Laura, Keuyalian, Avo, Boukhatem, Zakaria, Garcia, Claudia, Auclair, Francois, Bueschges, Ansgar and Dubuc, Rejean (2017). Nigral Glutamatergic Neurons Control the Speed of Locomotion. J. Neurosci., 37 (40). S. 9759 - 9771. WASHINGTON: SOC NEUROSCIENCE. ISSN 0270-6474

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Abstract

The mesencephalic locomotor region (MLR) plays a crucial role in locomotor control. In vertebrates, stimulation of the MLR at increasing intensities elicits locomotion of growing speed. This effect has been presumed to result from higher brain inputs activating the MLR like a dimmer switch. Here, we show in lampreys (Petromyzon marinus) of either sex that incremental stimulation of a region homologous to the mammalian substantia nigra pars compacta (SNc) evokes increasing activation of MLR cells with a graded increase in the frequency of locomotor movements. Neurons co-storing glutamate and dopamine were found to project from the primal SNc to the MLR. Blockade of glutamatergic transmission largely diminished MLR cell responses and locomotion. Local blockade of D-1 receptors in the MLR decreased locomotor frequency, but did not disrupt the SNc-evoked graded control of locomotion. Our findings revealed the presence of a glutamatergic input to the MLR originating from the primal SNc that evokes graded locomotor movements.

Item Type:	Journal Article
Creators:	Creators Email ORCID ORCID Put Code Ryczko, Dimitri UNSPECIFIED orcid.org/0000-0003-3948-7728 UNSPECIFIED Graetsch, Swantje UNSPECIFIED UNSPECIFIED UNSPECIFIED Schlager, Laura UNSPECIFIED UNSPECIFIED UNSPECIFIED Keuyalian, Avo UNSPECIFIED UNSPECIFIED UNSPECIFIED Boukhatem, Zakaria UNSPECIFIED UNSPECIFIED UNSPECIFIED Garcia, Claudia UNSPECIFIED UNSPECIFIED UNSPECIFIED Auclair, Francois UNSPECIFIED UNSPECIFIED UNSPECIFIED Bueschges, Ansgar UNSPECIFIED UNSPECIFIED UNSPECIFIED Dubuc, Rejean UNSPECIFIED UNSPECIFIED UNSPECIFIED
URN:	urn:nbn:de:hbz:38-214548
DOI:	10.1523/JNEUROSCI.1810-17.2017
Journal or Publication Title:	J. Neurosci.
Volume:	37
Number:	40
Page Range:	S. 9759 - 9771
Date:	2017
Publisher:	SOC NEUROSCIENCE
Place of Publication:	WASHINGTON
ISSN:	0270-6474
Language:	English
Faculty:	Unspecified
Divisions:	Unspecified
Subjects:	no entry
Uncontrolled Keywords:	Keywords Language CENTRAL-NERVOUS-SYSTEM; BASAL GANGLIA; BRAIN-STEM; RETICULOSPINAL NEURONS; DOPAMINE NEURONS; SEA LAMPREY; RETICULAR-FORMATION; SPINAL-CORD; REGION; MIDBRAIN Multiple languages Neurosciences Multiple languages
Refereed:	Yes
URI:	http://kups.ub.uni-koeln.de/id/eprint/21454