Universität zu Köln

de Vos, Marjon G. J., Zagorski, Marcin ORCID: 0000-0001-7896-7762, McNally, Alan ORCID: 0000-0002-3099-630X and Bollenbach, Tobias ORCID: 0000-0003-4398-476X (2017). Interaction networks, ecological stability, and collective antibiotic tolerance in polymicrobial infections. Proc. Natl. Acad. Sci. U. S. A., 114 (40). S. 10666 - 10672. WASHINGTON: NATL ACAD SCIENCES. ISSN 0027-8424

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Abstract

Polymicrobial infections constitute small ecosystems that accommodate several bacterial species. Commonly, these bacteria are investigated in isolation. However, it is unknown to what extent the isolates interact and whether their interactions alter bacterial growth and ecosystem resilience in the presence and absence of antibiotics. We quantified the complete ecological interaction network for 72 bacterial isolates collected from 23 individuals diagnosed with polymicrobial urinary tract infections and found that most interactions cluster based on evolutionary relatedness. Statistical network analysis revealed that competitive and cooperative reciprocal interactions are enriched in the global network, while cooperative interactions are depleted in the individual host community networks. A population dynamics model parameterized by our measurements suggests that interactions restrict community stability, explaining the observed species diversity of these communities. We further show that the clinical isolates frequently protect each other from clinically relevant antibiotics. Together, these results highlight that ecological interactions are crucial for the growth and survival of bacteria in polymicrobial infection communities and affect their assembly and resilience.

Item Type:	Journal Article
Creators:	Creators Email ORCID ORCID Put Code de Vos, Marjon G. J. UNSPECIFIED UNSPECIFIED UNSPECIFIED Zagorski, Marcin UNSPECIFIED orcid.org/0000-0001-7896-7762 UNSPECIFIED McNally, Alan UNSPECIFIED orcid.org/0000-0002-3099-630X UNSPECIFIED Bollenbach, Tobias UNSPECIFIED orcid.org/0000-0003-4398-476X UNSPECIFIED
URN:	urn:nbn:de:hbz:38-214573
DOI:	10.1073/pnas.1713372114
Journal or Publication Title:	Proc. Natl. Acad. Sci. U. S. A.
Volume:	114
Number:	40
Page Range:	S. 10666 - 10672
Date:	2017
Publisher:	NATL ACAD SCIENCES
Place of Publication:	WASHINGTON
ISSN:	0027-8424
Language:	English
Faculty:	Unspecified
Divisions:	Unspecified
Subjects:	no entry
Uncontrolled Keywords:	Keywords Language URINARY-TRACT-INFECTIONS; ESCHERICHIA-COLI; BACTERIAL COMMUNITY; HUMAN-DISEASE; MECHANISMS; COMPETITION; RESISTANCE; MICROBIOME; DIVERSITY; DYNAMICS Multiple languages Multidisciplinary Sciences Multiple languages
Refereed:	Yes
URI:	http://kups.ub.uni-koeln.de/id/eprint/21457