Universität zu Köln

Enders, Philip ORCID: 0000-0002-9527-4957, Bremen, Andreas, Schaub, Friederike, Hermann, Manuel M., Diestelhorst, Michael, Dietlein, Thomas, Cursiefen, Claus and Heindl, Ludwig M. (2017). Intraday Repeatability of Bruch's Membrane Opening-Based Neuroretinal Rim Measurements. Invest. Ophthalmol. Vis. Sci., 58 (12). S. 5195 - 5201. ROCKVILLE: ASSOC RESEARCH VISION OPHTHALMOLOGY INC. ISSN 1552-5783

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Abstract

PURPOSE. To assess possible intraday variability in Bruch's membrane opening-based (BMO) assessment of neuroretinal rim by spectral-domain optical coherence tomography (SD-OCT) of the optic nerve head (ONH) as well as to evaluate its independence from intraindividual IOP changes. METHODS. In this noninterventional, prospective cohort study, 51 consecutively enrolled patients with glaucoma or ocular hypertension underwent standardized SD-OCT of the ONH and IOP assessment at two different time points with a time gap of 5 hours on the same day. Random effects models, intraclass correlation coefficients (ICC) and Bland-Altman plots were used to analyze repeatability of BMO minimum rim width (BMO-MRW) and area (BMO-MRA) and peripapillary retinal nerve fiber layer (RNFL) thickness measurements. RESULTS. Mean BMO area was 1.86 +/- 0.30 mm(2). At baseline, mean BMO-MRW was 206.46 +/- 0.86 mu m, mean BMO-MRA was 0.89 +/- 0.34 mm(2), and mean RNFL thickness was 71.61 +/- 0.20 mu m. Within intraindividual measurements, mean difference was 2.95 mu m or 1.76% for BMO-MRW, 0.02 mm 2 or 2.68% for BMO-MRA, and 1.18 mu m or 1.89% for RNFL thickness. Comparing time points, eta(2) was 0.001 (P = 0.757) for RNFL thickness, 0.043 (P = 0.01) for BMO-MRA, and 0.07 (P = 0.06) for BMO-MRW. Intraclass correlation coefficients were greater than 0.994, respectively. Variability of morphometric parameters did not correlate to intraindividual IOP fluctuations. CONCLUSIONS. Assessment of BMO-MRW by SD-OCT shows high intraday repeatability, which is comparable to the parameter RNFL thickness. Variability seems not to be driven by typical moderate intraday fluctuations of IOP The two-dimensional parameter BMO-MRA incorporates a fairly higher intraindividual variability.

Item Type:	Journal Article
Creators:	Creators Email ORCID ORCID Put Code Enders, Philip UNSPECIFIED orcid.org/0000-0002-9527-4957 UNSPECIFIED Bremen, Andreas UNSPECIFIED UNSPECIFIED UNSPECIFIED Schaub, Friederike UNSPECIFIED UNSPECIFIED UNSPECIFIED Hermann, Manuel M. UNSPECIFIED UNSPECIFIED UNSPECIFIED Diestelhorst, Michael UNSPECIFIED UNSPECIFIED UNSPECIFIED Dietlein, Thomas UNSPECIFIED UNSPECIFIED UNSPECIFIED Cursiefen, Claus UNSPECIFIED UNSPECIFIED UNSPECIFIED Heindl, Ludwig M. UNSPECIFIED UNSPECIFIED UNSPECIFIED
URN:	urn:nbn:de:hbz:38-215555
DOI:	10.1167/iovs.17-22812
Journal or Publication Title:	Invest. Ophthalmol. Vis. Sci.
Volume:	58
Number:	12
Page Range:	S. 5195 - 5201
Date:	2017
Publisher:	ASSOC RESEARCH VISION OPHTHALMOLOGY INC
Place of Publication:	ROCKVILLE
ISSN:	1552-5783
Language:	English
Faculty:	Unspecified
Divisions:	Unspecified
Subjects:	no entry
Uncontrolled Keywords:	Keywords Language OPTICAL COHERENCE TOMOGRAPHY; INTRAOCULAR-PRESSURE MEASUREMENTS; SCANNING LASER OPHTHALMOSCOPY; FIBER LAYER THICKNESS; DISC MARGIN ANATOMY; NERVE HEAD; GLAUCOMA; POLARIMETRY; POPULATION; PERIMETRY Multiple languages Ophthalmology Multiple languages
Refereed:	Yes
URI:	http://kups.ub.uni-koeln.de/id/eprint/21555