Universität zu Köln

Xu, Hao, Zheng, Feng, Krischek, Boris, Ding, Wanhai, Xiong, Chi, Wang, Xin and Niu, Chaoshi (2017). Subthalamic nucleus and globus pallidus internus stimulation for the treatment of Parkinson's disease: A systematic review. J. Int. Med. Res., 45 (5). S. 1602 - 1613. LONDON: SAGE PUBLICATIONS LTD. ISSN 1473-2300

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Abstract

Objective Deep brain stimulation (DBS) for treatment of advanced Parkinson's disease (PD) has two anatomical targets: the subthalamic nucleus (STN) and the globus pallidus internus (GPI). The clinical effectiveness of these two stimulation targets was compared in the present study. Methods A systematic review and meta-analysis was performed to evaluated the postoperative changes in the United Parkinson's Disease Rating Scale (UPDRS) on- and off-phase, on-stimulation motor scores; activities of daily living score (ADLS); and levodopa equivalent dose (LED) after STN and GPI stimulation. Randomized and nonrandomized controlled trials of PD treated by STN and GPI stimulation were considered for inclusion. Results Eight published reports of eligible studies involving 599 patients met the inclusion criteria. No significant differences were observed between the STN and GPI groups in the on-medication, on-stimulation UPDRS motor score [mean difference, 2.15; 95% confidence interval (CI), -0.96-5.27] or ADLS (mean difference, 3.40; 95% CI, 0.95-7.76). Significant differences in favor of STN stimulation were noted in the off-medication, on-stimulation UPDRS motor score (mean difference, 1.67; 95% CI, 0.98-2.37) and LED (mean difference, 130.24; 95% CI, 28.82-231.65). Conclusion The STN may be the preferred target for DBS in consideration of medication reduction, economic efficiency, and motor function improvement in the off phase. However, treatment decisions should be made according to the individual patient's symptoms and expectations.

Item Type:	Journal Article
Creators:	Creators Email ORCID ORCID Put Code Xu, Hao UNSPECIFIED UNSPECIFIED UNSPECIFIED Zheng, Feng UNSPECIFIED UNSPECIFIED UNSPECIFIED Krischek, Boris UNSPECIFIED UNSPECIFIED UNSPECIFIED Ding, Wanhai UNSPECIFIED UNSPECIFIED UNSPECIFIED Xiong, Chi UNSPECIFIED UNSPECIFIED UNSPECIFIED Wang, Xin UNSPECIFIED UNSPECIFIED UNSPECIFIED Niu, Chaoshi UNSPECIFIED UNSPECIFIED UNSPECIFIED
URN:	urn:nbn:de:hbz:38-215651
DOI:	10.1177/0300060517708102
Journal or Publication Title:	J. Int. Med. Res.
Volume:	45
Number:	5
Page Range:	S. 1602 - 1613
Date:	2017
Publisher:	SAGE PUBLICATIONS LTD
Place of Publication:	LONDON
ISSN:	1473-2300
Language:	English
Faculty:	Unspecified
Divisions:	Unspecified
Subjects:	no entry
Uncontrolled Keywords:	Keywords Language DEEP-BRAIN-STIMULATION; QUALITY-OF-LIFE; BILATERAL STIMULATION; PALLIDOTOMY; MULTICENTER; COGNITION Multiple languages Medicine, Research & Experimental; Pharmacology & Pharmacy Multiple languages
Refereed:	Yes
URI:	http://kups.ub.uni-koeln.de/id/eprint/21565