Universität zu Köln

Fiege, J., Mainz, J. G., Tabori, H., Renz, D. M., Stenzel, M. and Mentzel, H. -J. (2017). ARFI elastography of cystic fibrosis-related liver disease (CFLD). Mon.schr. Kinderheilkd., 165 (10). S. 888 - 895. NEW YORK: SPRINGER. ISSN 1433-0474

Full text not available from this repository.

Abstract

At present, no gold standard has been defined for the assessment of cystic fibrosis-related liver disease (CFLD). Acoustic radiation force impulse (ARFI) imaging is a non-invasive, radiation-free method to measure stiffness of the liver. To assess ARFI imaging cut-off values for CFLD and identify parameters that could potentially influence ARFI imaging results. Longitudinal changes of a subgroup of CF patients were investigated. ARFI was applied in 86 CF patients with the ultrasound device iU22 (Philips Healthcare) and a C5-1 MHz device in segment VII. The patients were divided into two groups based on the presence or absence of CFLD (n = 29/86 CFLD+), which was determined according to laboratory values, hepatomegaly or splenomegaly, and the Wilson score. After an average of 11 months, 48 CF patients were longitudinally revaluated. Significant differences (p < 0.001) were found regarding ARFI imaging values of patients with and without CFLD. Medians of CFLD+ patients resulted in c = 1.07 +/- 0.12 m/s compared to c = 1.46 +/- 0.33 m/s in the CFLD- group. Significantly higher values were found in males compared to females and in patients with a history of meconium ileus. Age and BMI did not influence results. In the longitudinal assessment after an average of 11 months, only a marginal increase of 1.77 % for the CFLD- and 6.56 % for CFLD+ groups were found. Our results show that ARFI imaging is a valid parameter to assess liver involvement in patients with CF.

Item Type:	Journal Article
Creators:	Creators Email ORCID ORCID Put Code Fiege, J. UNSPECIFIED UNSPECIFIED UNSPECIFIED Mainz, J. G. UNSPECIFIED UNSPECIFIED UNSPECIFIED Tabori, H. UNSPECIFIED UNSPECIFIED UNSPECIFIED Renz, D. M. UNSPECIFIED UNSPECIFIED UNSPECIFIED Stenzel, M. UNSPECIFIED UNSPECIFIED UNSPECIFIED Mentzel, H. -J. UNSPECIFIED UNSPECIFIED UNSPECIFIED
URN:	urn:nbn:de:hbz:38-215784
DOI:	10.1007/s00112-016-0197-5
Journal or Publication Title:	Mon.schr. Kinderheilkd.
Volume:	165
Number:	10
Page Range:	S. 888 - 895
Date:	2017
Publisher:	SPRINGER
Place of Publication:	NEW YORK
ISSN:	1433-0474
Language:	German
Faculty:	Unspecified
Divisions:	Unspecified
Subjects:	no entry
Uncontrolled Keywords:	Keywords Language IMPULSE IMAGING ARFI; HEALTHY-CHILDREN; NORMAL VALUES; RADIATION; STIFFNESS; TISSUE Multiple languages Pediatrics Multiple languages
Refereed:	Yes
URI:	http://kups.ub.uni-koeln.de/id/eprint/21578