Universität zu Köln

Hammes, Jochen, Bischof, Gerard N. and Drzezga, Alexander (2017). Molecular imaging in early diagnosis, differential diagnosis and follow-up of patients with neurodegenerative diseases. Clin. Transl. Imaging, 5 (5). S. 465 - 472. MILAN: SPRINGER-VERLAG ITALIA SRL. ISSN 2281-7565

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Abstract

Purpose Current disease models suggest that many neurodegenerative disorders are associated with pathological protein aggregations that start to develop in the brain long before the onset of clinical symptoms. Therefore, biomarkers allowing early and reliable characterization of neurodegenerative disease are required. Here we illustrate the potential value of neuroimaging procedures by means of selected examples. Methods Multimodal imaging data of exemplary patients who underwent FDG, Amyloid and AV-1451-PET, FPCIT-SPECT and MRI imaging in the routine clinical workup in our department is presented and the currently available literature on the topic of imaging in neurodegenerative diseases was reviewed. Results The complementary value of the applied imaging methods is demonstrated in pairs of representative cases. Depending on the clinical question, individual methods or a meaningful multimodal combination is required to achieve optimal diagnostic benefit. Conclusion Imaging biomarkers have high potential for early diagnosis, differential diagnosis and follow-up of patients with neurodegenerative diseases already and will pathology-targeted therapies will be evaluated in clinical trials.

Item Type:	Journal Article
Creators:	Creators Email ORCID ORCID Put Code Hammes, Jochen UNSPECIFIED UNSPECIFIED UNSPECIFIED Bischof, Gerard N. UNSPECIFIED UNSPECIFIED UNSPECIFIED Drzezga, Alexander UNSPECIFIED UNSPECIFIED UNSPECIFIED
URN:	urn:nbn:de:hbz:38-216183
DOI:	10.1007/s40336-017-0242-y
Journal or Publication Title:	Clin. Transl. Imaging
Volume:	5
Number:	5
Page Range:	S. 465 - 472
Date:	2017
Publisher:	SPRINGER-VERLAG ITALIA SRL
Place of Publication:	MILAN
ISSN:	2281-7565
Language:	English
Faculty:	Unspecified
Divisions:	Unspecified
Subjects:	no entry
Uncontrolled Keywords:	Keywords Language ALZHEIMERS ASSOCIATION WORKGROUPS; PARKINSONS-DISEASE; NATIONAL INSTITUTE; COGNITIVE IMPAIRMENT; LEWY BODIES; A-BETA; RECOMMENDATIONS; GUIDELINES; DEMENTIA; TAU Multiple languages Radiology, Nuclear Medicine & Medical Imaging Multiple languages
Refereed:	Yes
URI:	http://kups.ub.uni-koeln.de/id/eprint/21618