Universität zu Köln

Zhang, Xintong, Chen, Lei, Zheng, Feng and Du, Yanli (2017). The efficacy of microsurgery in the treatment of cerebral aneurysm rupture and its effect on NF-kappa B, MCP-1 and MMP-9. Exp. Ther. Med., 14 (4). S. 3744 - 3749. ATHENS: SPANDIDOS PUBL LTD. ISSN 1792-1015

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Abstract

The clinical efficacy of microsurgical neck clipping for the treatment of cerebral aneurysm rupture and its effect on serum nuclear factor kappa-light-chain-enhancer of activated beta cells (NF-kappa B), monocyte chemoattractant protein-1 (MCP-1) and matrix metalloproteinase-9-9 (MMP-9-9) levels were investigated. A total of 56 patients with first occurrence of cerebral aneurysm rupture were enrolled from June 2015 to June 2016. These patients were divided into control (25 patients) and observation groups (31 patients) according to treatment received. The patients in the control group were treated with interventional embolization and extraventricular drainage, while the patients in the observation group were treated with microsurgical neck clipping. Serum NF-kappa B, MCP-1 and MMP-9-9 levels were measured by ELISA prior to the operation and at 6 h post-operation. Clinical effects were compared at the 6-month follow-up. There was no significant difference in the success rate of the operation between the two groups (p>0.05). The incidence of complications in the observation group was significantly lower than that in the control group (p<0.05). The Glasgow Outcome Scale score was significantly improved in the observation group (p<0.05) compared with the control group. Serum NF-kappa B, MMP-9-9 and MCP-1 were significantly decreased in both groups at 6 and 24 h after operation, but the observational group showed significantly lower levels for all three proteins than the control group (p<0.05). The application of early microsurgical neck clipping for the treatment of cerebral aneurysm rupture can reduce complications and improve clinical prognosis, and this may be related to a decrease in serum inflammatory response-related factors (NF-kappa B and MCP-1) and MMP-9-9.

Item Type:	Journal Article
Creators:	Creators Email ORCID ORCID Put Code Zhang, Xintong UNSPECIFIED UNSPECIFIED UNSPECIFIED Chen, Lei UNSPECIFIED UNSPECIFIED UNSPECIFIED Zheng, Feng UNSPECIFIED UNSPECIFIED UNSPECIFIED Du, Yanli UNSPECIFIED UNSPECIFIED UNSPECIFIED
URN:	urn:nbn:de:hbz:38-216208
DOI:	10.3892/etm.2017.4928
Journal or Publication Title:	Exp. Ther. Med.
Volume:	14
Number:	4
Page Range:	S. 3744 - 3749
Date:	2017
Publisher:	SPANDIDOS PUBL LTD
Place of Publication:	ATHENS
ISSN:	1792-1015
Language:	English
Faculty:	Unspecified
Divisions:	Unspecified
Subjects:	no entry
Uncontrolled Keywords:	Keywords Language INTRACRANIAL ANEURYSMS; COIL EMBOLIZATION; BIOLOGY; RISK Multiple languages Medicine, Research & Experimental Multiple languages
Refereed:	Yes
URI:	http://kups.ub.uni-koeln.de/id/eprint/21620