Universität zu Köln

Walther, Grit, Stasch, Serena, Kaerger, Kerstin, Hamprecht, Axel ORCID: 0000-0003-1449-5780, Roth, Mathias, Cornely, Oliver A., Geerling, Gerd, Mackenzie, Colin R., Kurzai, Oliver and von Lilienfeld-Toal, Marie (2017). Fusarium Keratitis in Germany. J. Clin. Microbiol., 55 (10). S. 2983 - 2996. WASHINGTON: AMER SOC MICROBIOLOGY. ISSN 1098-660X

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Abstract

Fusarium keratitis is a destructive eye infection that is difficult to treat and results in poor outcome. In tropical and subtropical areas, the infection is relatively common and associated with trauma or chronic eye diseases. However, in recent years, an increased incidence has been reported in temperate climate regions. At the German National Reference Center, we have observed a steady increase in case numbers since 2014. Here, we present the first German case series of eye infections with Fusarium species. We identified Fusarium isolates from the eye or eye-related material from 22 patients in 2014 and 2015. Thirteen isolates belonged to the Fusarium solani species complex (FSSC), 6 isolates belonged to the Fusarium oxysporum species complex (FOSC), and three isolates belonged to the Fusarium fujikuroi species complex (FFSC). FSSC was isolated in 13 of 15 (85%) definite infections and FOSC in 3 of 4 (75%) definite contaminations. Furthermore, diagnosis from contact lens swabs or a culture of contact lens solution turned out to be highly unreliable. FSSC isolates differed from FOSC and FFSC by a distinctly higher MIC for terbinafine. Outcome was often adverse, with 10 patients requiring keratoplasty or enucleation. The use of natamycin as the most effective agent against keratitis caused by filamentous fungi was rare in Germany, possibly due to restricted availability. Keratitis caused by Fusarium spp. (usually FSSC) appears to be a relevant clinical problem in Germany, with the use of contact lenses as the predominant risk factor. Its outcome is often adverse.

Item Type:	Journal Article
Creators:	Creators Email ORCID ORCID Put Code Walther, Grit UNSPECIFIED UNSPECIFIED UNSPECIFIED Stasch, Serena UNSPECIFIED UNSPECIFIED UNSPECIFIED Kaerger, Kerstin UNSPECIFIED UNSPECIFIED UNSPECIFIED Hamprecht, Axel UNSPECIFIED orcid.org/0000-0003-1449-5780 UNSPECIFIED Roth, Mathias UNSPECIFIED UNSPECIFIED UNSPECIFIED Cornely, Oliver A. UNSPECIFIED UNSPECIFIED UNSPECIFIED Geerling, Gerd UNSPECIFIED UNSPECIFIED UNSPECIFIED Mackenzie, Colin R. UNSPECIFIED UNSPECIFIED UNSPECIFIED Kurzai, Oliver UNSPECIFIED UNSPECIFIED UNSPECIFIED von Lilienfeld-Toal, Marie UNSPECIFIED UNSPECIFIED UNSPECIFIED
URN:	urn:nbn:de:hbz:38-216295
DOI:	10.1128/JCM.00649-17
Journal or Publication Title:	J. Clin. Microbiol.
Volume:	55
Number:	10
Page Range:	S. 2983 - 2996
Date:	2017
Publisher:	AMER SOC MICROBIOLOGY
Place of Publication:	WASHINGTON
ISSN:	1098-660X
Language:	English
Faculty:	Unspecified
Divisions:	Unspecified
Subjects:	no entry
Uncontrolled Keywords:	Keywords Language IN-VITRO SUSCEPTIBILITY; SOLANI SPECIES COMPLEX; CONTACT-LENS SOLUTION; EYE CARE CENTER; FUNGAL KERATITIS; FILAMENTOUS FUNGI; PHYLOGENETIC DIVERSITY; MOLECULAR METHODS; AMPHOTERICIN-B; OUTBREAK Multiple languages Microbiology Multiple languages
Refereed:	Yes
URI:	http://kups.ub.uni-koeln.de/id/eprint/21629