Universität zu Köln

Kvasnicka, Hans Michael, Orazi, Attilio, Thiele, Juergen, Barosi, Giovanni, Bueso-Ramos, Carlos E., Vannucchi, Alessandro M., Hasserjian, Robert P., Kiladjian, Jean-Jacques ORCID: 0000-0002-8121-438X, Gianelli, Umberto, Silver, Richard, Mughal, Tariq I. and Barbui, Tiziano (2017). European LeukemiaNet study on the reproducibility of bone marrow features in masked polycythemia vera and differentiation from essential thrombocythemia. Am. J. Hematol., 92 (10). S. 1062 - 1068. HOBOKEN: WILEY. ISSN 1096-8652

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Abstract

The purpose of the study was to assess consensus and interobserver agreement among an international panel of six hematopathologists regarding characterization and reproducibility of bone marrow (BM) histologic features used to diagnose early stage myeloproliferative neoplasms, in particular differentiation of so-called masked/prodromal polycythemia vera (mPV) from JAK2-mutated essential thrombocythemia (ET). The six members of the hematopathology panel evaluated 98 BM specimens independently and in a blinded fashion without knowledge of clinical data. The specimens included 48 cases of mPV according to the originally published hemoglobin threshold values for this entity (male: 16.0-18.4 g/dL, female: 15.0-16.4 g/dL), 31 cases with overt PV according to the updated 2016 WHO criteria, and 19 control cases. The latter group included cases of JAK2-mutated ET, primary myelofibrosis, myelodysplastic syndrome, and various reactive conditions. Inter-rater agreement between the panelists was very high (overall agreement 92.6%, kappa 0.812), particularly with respect to separating mPV from ET. Virtually all cases of mPV were correctly classified as PV according to their BM morphology. In conclusion, a central blinded review of histology slides by six hematopathologists demonstrated that highly reproducible specific histological pattern characterize PV and confirmed the notion that there are no significant differences between mPV and overt PV in relation to BM morphology.

Item Type:	Journal Article
Creators:	Creators Email ORCID ORCID Put Code Kvasnicka, Hans Michael UNSPECIFIED UNSPECIFIED UNSPECIFIED Orazi, Attilio UNSPECIFIED UNSPECIFIED UNSPECIFIED Thiele, Juergen UNSPECIFIED UNSPECIFIED UNSPECIFIED Barosi, Giovanni UNSPECIFIED UNSPECIFIED UNSPECIFIED Bueso-Ramos, Carlos E. UNSPECIFIED UNSPECIFIED UNSPECIFIED Vannucchi, Alessandro M. UNSPECIFIED UNSPECIFIED UNSPECIFIED Hasserjian, Robert P. UNSPECIFIED UNSPECIFIED UNSPECIFIED Kiladjian, Jean-Jacques UNSPECIFIED orcid.org/0000-0002-8121-438X UNSPECIFIED Gianelli, Umberto UNSPECIFIED UNSPECIFIED UNSPECIFIED Silver, Richard UNSPECIFIED UNSPECIFIED UNSPECIFIED Mughal, Tariq I. UNSPECIFIED UNSPECIFIED UNSPECIFIED Barbui, Tiziano UNSPECIFIED UNSPECIFIED UNSPECIFIED
URN:	urn:nbn:de:hbz:38-217194
DOI:	10.1002/ajh.24837
Journal or Publication Title:	Am. J. Hematol.
Volume:	92
Number:	10
Page Range:	S. 1062 - 1068
Date:	2017
Publisher:	WILEY
Place of Publication:	HOBOKEN
ISSN:	1096-8652
Language:	English
Faculty:	Unspecified
Divisions:	Unspecified
Subjects:	no entry
Uncontrolled Keywords:	Keywords Language DIAGNOSTIC-CRITERIA; PRIMARY MYELOFIBROSIS; MUTATION STATUS; CLASSIFICATION; IMPACT; JAK2; POLYCYTHAEMIA/ERYTHROCYTOSIS; MANAGEMENT; NEOPLASMS; SURVIVAL Multiple languages Hematology Multiple languages
Refereed:	Yes
URI:	http://kups.ub.uni-koeln.de/id/eprint/21719