Universität zu Köln

Koy, T., Ganse, B., Zange, J., Rittweger, J., Pohle-Froehlich, R., Fings-Meuthen, P., Johannes, B., Felsenberg, D., Eysel, P., Bansmann, P. M. and Belavy, D. L. (2017). T2-relaxation time increases in lumbar intervertebral discs after 21d head-down tilt bed-rest. J. Musculoskelet. Neuronal Interact., 17 (3). S. 140 - 146. NAFPLION: JMNI. ISSN 1108-7161

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Abstract

Objectives: Spaceflight back pain and intervertebral disc (IVD) herniations cause problems in astronauts. Purpose of this study was to assess changes in T2-relaxation-time through MRI measurements before and after head-down tilt bed-rest, a spaceflight analog. Methods: 8 men participated in the bed-rest study. Subjects remained in 6 degrees head down tilt bed-rest in two campaigns of 21 days, and received a nutritional intervention (potassium bicarbonate 90 mmol/d) in a cross-over design. MRI measurements were performed 2 days before bed-rest, as well as one and five days after getting up. Image segmentation and data analysis were conducted for the IVDs Th12/L1 to L5/S1. Results: 7 subjects, average age of 27.6 (SD 3.3) years, completed the study. Results showed a significant increase in T2-time in all IVDs (p < 0.001), more pronounced in the nucleus pulposus than in the annulus fibrosus (p< 0.001). Oral potassium bicarbonate did not show an effect (p=0.443). Pfirrmann-grade correlated with the T2-time (p< 0.001). Conclusions: 6 degrees head-down tilt bed-rest leads to a T2-time increase in lumbar IVDs. Oral potassium bicarbonate supplementation does not have an effect on IVD T2-time.

Item Type:	Journal Article
Creators:	Creators Email ORCID ORCID Put Code Koy, T. UNSPECIFIED UNSPECIFIED UNSPECIFIED Ganse, B. UNSPECIFIED UNSPECIFIED UNSPECIFIED Zange, J. UNSPECIFIED UNSPECIFIED UNSPECIFIED Rittweger, J. UNSPECIFIED UNSPECIFIED UNSPECIFIED Pohle-Froehlich, R. UNSPECIFIED UNSPECIFIED UNSPECIFIED Fings-Meuthen, P. UNSPECIFIED UNSPECIFIED UNSPECIFIED Johannes, B. UNSPECIFIED UNSPECIFIED UNSPECIFIED Felsenberg, D. UNSPECIFIED UNSPECIFIED UNSPECIFIED Eysel, P. UNSPECIFIED UNSPECIFIED UNSPECIFIED Bansmann, P. M. UNSPECIFIED UNSPECIFIED UNSPECIFIED Belavy, D. L. UNSPECIFIED UNSPECIFIED UNSPECIFIED
URN:	urn:nbn:de:hbz:38-219944
Journal or Publication Title:	J. Musculoskelet. Neuronal Interact.
Volume:	17
Number:	3
Page Range:	S. 140 - 146
Date:	2017
Publisher:	JMNI
Place of Publication:	NAFPLION
ISSN:	1108-7161
Language:	English
Faculty:	Unspecified
Divisions:	Unspecified
Subjects:	no entry
Uncontrolled Keywords:	Keywords Language T2 RELAXATION-TIMES; LOW-BACK-PAIN; 3.0 TESLA; DEGENERATION; MICROGRAVITY; ASTRONAUTS; MRI; SPACEFLIGHT; SPINE; US Multiple languages Neurosciences; Physiology Multiple languages
Refereed:	Yes
URI:	http://kups.ub.uni-koeln.de/id/eprint/21994