Dumitrescu, Daniel, Sitbon, Olivier ORCID: 0000-0002-1942-1951, Weatherald, Jason and Howard, Luke S. (2017). Exertional dyspnoea in pulmonary arterial hypertension. Eur. Respir. Rev., 26 (145). SHEFFIELD: EUROPEAN RESPIRATORY SOC JOURNALS LTD. ISSN 1600-0617

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Abstract

Dyspnoea is a principal presenting symptom in pulmonary arterial hypertension (PAH), and often the most distressing. The pathophysiology of PAH is relatively well understood, with the primary abnormality of pulmonary vascular disease resulting in a combination of impaired cardiac output on exercise and abnormal gas exchange, both contributing to increased ventilatory drive. However, increased ventilatory drive is not the sole explanation for the complex neurophysiological and neuropsychological symptom of dyspnoea, with other significant contributions from skeletal muscle reflexes, respiratory muscle function, and psychological and emotional status. In this review, we explore the physiological aspects of dyspnoea in PAH, both in terms of the central cardiopulmonary abnormalities of PAH and the wider, systemic impact of PAH, and how these interact with common comorbidities. Finally, we discuss its relationship with disease severity.

Item Type: Journal Article
Creators:
CreatorsEmailORCIDORCID Put Code
Dumitrescu, DanielUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Sitbon, OlivierUNSPECIFIEDorcid.org/0000-0002-1942-1951UNSPECIFIED
Weatherald, JasonUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Howard, Luke S.UNSPECIFIEDUNSPECIFIEDUNSPECIFIED
URN: urn:nbn:de:hbz:38-220702
DOI: 10.1183/16000617.0039-2017
Journal or Publication Title: Eur. Respir. Rev.
Volume: 26
Number: 145
Date: 2017
Publisher: EUROPEAN RESPIRATORY SOC JOURNALS LTD
Place of Publication: SHEFFIELD
ISSN: 1600-0617
Language: English
Faculty: Unspecified
Divisions: Unspecified
Subjects: no entry
Uncontrolled Keywords:
KeywordsLanguage
CHRONIC HEART-FAILURE; EXERCISE CAPACITY; VENTILATORY INEFFICIENCY; PROGNOSTIC-SIGNIFICANCE; OXYGEN EXTRACTION; SKELETAL-MUSCLE; IRON-DEFICIENCY; CARBON-DIOXIDE; STROKE VOLUME; GAS-EXCHANGEMultiple languages
Respiratory SystemMultiple languages
Refereed: Yes
URI: http://kups.ub.uni-koeln.de/id/eprint/22070

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