Universität zu Köln

Genon, Sarah, Wensing, Tobias ORCID: 0000-0003-4791-2691, Reid, Andrew ORCID: 0000-0002-0523-926X, Hoffstaedter, Felix ORCID: 0000-0001-7163-3110, Caspers, Svenja ORCID: 0000-0001-5083-4669, Grefkes, Christian ORCID: 0000-0002-1656-720X, Nickl-Jockschat, Thomas ORCID: 0000-0003-2616-6503 and Eickhoff, Simon B. ORCID: 0000-0001-6363-2759 (2017). Searching for behavior relating to grey matter volume in a-priori defined right dorsal premotor regions: Lessons learned. Neuroimage, 157. S. 144 - 157. SAN DIEGO: ACADEMIC PRESS INC ELSEVIER SCIENCE. ISSN 1095-9572

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Abstract

Recently, we showed that the functional heterogeneity of the right dorsal premotor (PMd) cortex could be better understood by dividing it into five subregions that showed different behavioral associations according to task-based activations studies. The present study investigated whether the revealed behavioral profile could be corroborated and complemented by a structural brain behavior correlation approach in two healthy adults cohorts. Grey matter volume within the five volumes of interest (VOI-GM) was computed using voxel-based morphometry. Associations between the inter-individual differences in VOI-GM and performance across a range of neuropsychological tests were assessed in the two cohorts with and without correction for demographical variables. Additional analyses were performed in random smaller subsamples drawn from each of the two cohorts. In both cohorts, correlation coefficients were low; only few were significant and a considerable number of correlations were counterintuitive in their directions (i.e., higher performance related to lower grey matter volume). Furthermore, correlation patterns were inconsistent between the two cohorts. Subsampling revealed that correlation patterns could vary widely across small samples and that negative correlations were as likely as positive correlations. Thus, the structural brain-behavior approach did not corroborate the functional profiles of the PMd subregions inferred from activation studies, suggesting that local recruitment by fMRI studies does not necessarily imply covariance of local structure with behavioral performance in healthy adults. We discuss the limitations of such studies and related recommendations for future studies.

Item Type:	Journal Article
Creators:	Creators Email ORCID ORCID Put Code Genon, Sarah UNSPECIFIED UNSPECIFIED UNSPECIFIED Wensing, Tobias UNSPECIFIED orcid.org/0000-0003-4791-2691 UNSPECIFIED Reid, Andrew UNSPECIFIED orcid.org/0000-0002-0523-926X UNSPECIFIED Hoffstaedter, Felix UNSPECIFIED orcid.org/0000-0001-7163-3110 UNSPECIFIED Caspers, Svenja UNSPECIFIED orcid.org/0000-0001-5083-4669 UNSPECIFIED Grefkes, Christian UNSPECIFIED orcid.org/0000-0002-1656-720X UNSPECIFIED Nickl-Jockschat, Thomas UNSPECIFIED orcid.org/0000-0003-2616-6503 UNSPECIFIED Eickhoff, Simon B. UNSPECIFIED orcid.org/0000-0001-6363-2759 UNSPECIFIED
URN:	urn:nbn:de:hbz:38-221739
DOI:	10.1016/j.neuroimage.2017.05.053
Journal or Publication Title:	Neuroimage
Volume:	157
Page Range:	S. 144 - 157
Date:	2017
Publisher:	ACADEMIC PRESS INC ELSEVIER SCIENCE
Place of Publication:	SAN DIEGO
ISSN:	1095-9572
Language:	English
Faculty:	Unspecified
Divisions:	Unspecified
Subjects:	no entry
Uncontrolled Keywords:	Keywords Language BOEKEL ET-AL.; INTERINDIVIDUAL DIFFERENCES; CONFIRMATORY REPLICATION; INDIVIDUAL-DIFFERENCES; EXECUTIVE FUNCTIONS; CORTICAL THICKNESS; SURFACE-AREA; SAMPLE-SIZE; BRAIN; CORTEX Multiple languages Neurosciences; Neuroimaging; Radiology, Nuclear Medicine & Medical Imaging Multiple languages
Refereed:	Yes
URI:	http://kups.ub.uni-koeln.de/id/eprint/22173