Universität zu Köln

Woehrle, Holger, Cowie, Martin R., Eulenburg, Christine, Suling, Anna, Angermann, Christiane, d'Ortho, Marie-Pia, Erdmann, Erland, Levy, Patrick, Simonds, Anita K., Somers, Virend K., Zannad, Faiez, Teschler, Helmut and Wegscheider, Karl (2017). Adaptive servo ventilation for central sleep apnoea in heart failure: SERVE-HF on-treatment analysis. Eur. Resp. J., 50 (2). SHEFFIELD: EUROPEAN RESPIRATORY SOC JOURNALS LTD. ISSN 1399-3003

Full text not available from this repository.

Abstract

This on-treatment analysis was conducted to facilitate understanding of mechanisms underlying the increased risk of all-cause and cardiovascular mortality in heart failure patients with reduced ejection fraction and predominant central sleep apnoea randomised to adaptive servo ventilation versus the control group in the SERVE-HF trial. Time-dependent on-treatment analyses were conducted (unadjusted and adjusted for predictive covariates). A comprehensive, time-dependent model was developed to correct for asymmetric selection effects (to minimise bias). The comprehensive model showed increased cardiovascular death hazard ratios during adaptive servo ventilation usage periods, slightly lower than those in the SERVE-HF intention-to-treat analysis. Self-selection bias was evident. Patients randomised to adaptive servo ventilation who crossed over to the control group were at higher risk of cardiovascular death than controls, while control patients with crossover to adaptive servo ventilation showed a trend towards lower risk of cardiovascular death than patients randomised to adaptive servo ventilation. Cardiovascular risk did not increase as nightly adaptive servo ventilation usage increased. On-treatment analysis showed similar results to the SERVE-HF intention-to-treat analysis, with an increased risk of cardiovascular death in heart failure with reduced ejection fraction patients with predominant central sleep apnoea treated with adaptive servo ventilation. Bias is inevitable and needs to be taken into account in any kind of on-treatment analysis in positive airway pressure studies.

Item Type:	Journal Article
Creators:	Creators Email ORCID ORCID Put Code Woehrle, Holger UNSPECIFIED UNSPECIFIED UNSPECIFIED Cowie, Martin R. UNSPECIFIED UNSPECIFIED UNSPECIFIED Eulenburg, Christine UNSPECIFIED UNSPECIFIED UNSPECIFIED Suling, Anna UNSPECIFIED UNSPECIFIED UNSPECIFIED Angermann, Christiane UNSPECIFIED UNSPECIFIED UNSPECIFIED d'Ortho, Marie-Pia UNSPECIFIED UNSPECIFIED UNSPECIFIED Erdmann, Erland UNSPECIFIED UNSPECIFIED UNSPECIFIED Levy, Patrick UNSPECIFIED UNSPECIFIED UNSPECIFIED Simonds, Anita K. UNSPECIFIED UNSPECIFIED UNSPECIFIED Somers, Virend K. UNSPECIFIED UNSPECIFIED UNSPECIFIED Zannad, Faiez UNSPECIFIED UNSPECIFIED UNSPECIFIED Teschler, Helmut UNSPECIFIED UNSPECIFIED UNSPECIFIED Wegscheider, Karl UNSPECIFIED UNSPECIFIED UNSPECIFIED
URN:	urn:nbn:de:hbz:38-222157
DOI:	10.1183/13993003.01692-2016
Journal or Publication Title:	Eur. Resp. J.
Volume:	50
Number:	2
Date:	2017
Publisher:	EUROPEAN RESPIRATORY SOC JOURNALS LTD
Place of Publication:	SHEFFIELD
ISSN:	1399-3003
Language:	English
Faculty:	Unspecified
Divisions:	Unspecified
Subjects:	no entry
Uncontrolled Keywords:	Keywords Language CHEYNE-STOKES RESPIRATION; POSITIVE AIRWAY PRESSURE; CARDIOVASCULAR-DISEASE; BLOOD-PRESSURE; CONTROLLED-TRIAL; SERVOVENTILATION; PREDICTORS; MORTALITY; ADHERENCE; DYSFUNCTION Multiple languages Respiratory System Multiple languages
Refereed:	Yes
URI:	http://kups.ub.uni-koeln.de/id/eprint/22215