Appel, Sarah, Schulze-Edinghausen, Merle, Kretschmer, Tobias ORCID: 0000-0002-4202-0806, Storck, Sarah, Janoschek, Ruth, Bae-Gartz, Inga, Handwerk, Marion, Wohlfarth, Maria, Nuesken, Kai -Dietrich, Hucklenbruch-Rother, Eva, Heykants, Malte, Mahabir, Esther and Doetsch, Joerg (2017). Maternal obesity attenuates predelivery inflammatory reaction in C57BL/6N mice. J. Reprod. Immunol., 122. S. 10 - 14. CLARE: ELSEVIER IRELAND LTD. ISSN 1872-7603

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Abstract

Inflammation and oxidative stress are known to increase before labour. Whether gonadal white adipose tissue (gWAT) participates in this process and whether labour-related processes in placental and adipose tissue are altered in obese women is unknown. In our mouse model, lean mice display elevated placental inflammation and oxidative stress towards the end of pregnancy, accompanied by an increased expression of pro-inflammatory factors in gWAT. Obese mice also display elevated levels of pro-inflammatory factors and oxidative stress in placentas shortly before birth. However, placental infiltration with leukocytes and an increase in gWAT pro inflammatory factor expression in obese dams are lacking.

Item Type: Journal Article
Creators:
CreatorsEmailORCIDORCID Put Code
Appel, SarahUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Schulze-Edinghausen, MerleUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Kretschmer, TobiasUNSPECIFIEDorcid.org/0000-0002-4202-0806UNSPECIFIED
Storck, SarahUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Janoschek, RuthUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Bae-Gartz, IngaUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Handwerk, MarionUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Wohlfarth, MariaUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Nuesken, Kai -DietrichUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Hucklenbruch-Rother, EvaUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Heykants, MalteUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Mahabir, EstherUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Doetsch, JoergUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
URN: urn:nbn:de:hbz:38-222170
DOI: 10.1016/j.jri.2017.06.004
Journal or Publication Title: J. Reprod. Immunol.
Volume: 122
Page Range: S. 10 - 14
Date: 2017
Publisher: ELSEVIER IRELAND LTD
Place of Publication: CLARE
ISSN: 1872-7603
Language: English
Faculty: Unspecified
Divisions: Unspecified
Subjects: no entry
Uncontrolled Keywords:
KeywordsLanguage
ADIPOSE-TISSUE; ONSET; LABORMultiple languages
Immunology; Reproductive BiologyMultiple languages
Refereed: Yes
URI: http://kups.ub.uni-koeln.de/id/eprint/22217

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