Universität zu Köln

Laufer, Guenther, Haverich, Axel, Andreas, Martin ORCID: 0000-0003-4950-5432, Mohr, Friedrich W., Walther, Thomas, Shrestha, Malakh, Rahmanian, Parwis, Holzhey, David ORCID: 0000-0002-0613-4419, Roth, Matthias, Schmitz, Christoph, Schramm, Rene, Giot, Christophe and Wahlers, Thorsten C. W. (2017). Long-term outcomes of a rapid deployment aortic valve: data up to 5 years. Eur. J. Cardio-Thorac. Surg., 52 (2). S. 281 - 288. CARY: OXFORD UNIV PRESS INC. ISSN 1873-734X

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Abstract

OBJECTIVES: Rapid deployment aortic valve replacement (AVR) has been developed to facilitate minimally invasive approaches for cardiac surgery and shorten procedural times. TRITON is a prospectively designed study to assess safety and efficacy of rapid deployment AVR with Edwards INTUITY valve system. This report presents the 5-year outcomes of the TRITON trial. METHODS: A total of 295 patients with aortic valve stenosis were enrolled in the TRITON trial and 287 patients received the study valve. Procedural, early (<= 30 days) and late (>30 days) outcomes were collected. Valve haemodynamic performance was evaluated at specified time points by an independent Echocardiography Core Laboratory and clinical events adjudicated by an independent Clinical Events Committee. RESULTS: Mean age was 75.3 +/- 6.7 years. A total of 158 patients underwent isolated AVR and 129 patients underwent AVR with concomitant procedures. The 5-year survival rates were 85.7 +/- 3.4% and 75.2 +/- 4.9% for isolated AVR and concomitant AVR, respectively. Overall, freedom from valve-related death at 5 years was 98.2 +/- 0.8%. At 5 years, the valve effective orifice area was 1.6 +/- 0.3cm(2), mean gradient was 10.5 +/- 5.4 mmHg and peak gradient was 18.9 +/- 9.3 mmHg. CONCLUSIONS: The 5-year outcomes of the TRITON trial demonstrate acceptable long-term safety and excellent haemodynamic performance of rapid deployment AVR with the Edwards INTUITY valve system.

Item Type:	Journal Article
Creators:	Creators Email ORCID ORCID Put Code Laufer, Guenther UNSPECIFIED UNSPECIFIED UNSPECIFIED Haverich, Axel UNSPECIFIED UNSPECIFIED UNSPECIFIED Andreas, Martin UNSPECIFIED orcid.org/0000-0003-4950-5432 UNSPECIFIED Mohr, Friedrich W. UNSPECIFIED UNSPECIFIED UNSPECIFIED Walther, Thomas UNSPECIFIED UNSPECIFIED UNSPECIFIED Shrestha, Malakh UNSPECIFIED UNSPECIFIED UNSPECIFIED Rahmanian, Parwis UNSPECIFIED UNSPECIFIED UNSPECIFIED Holzhey, David UNSPECIFIED orcid.org/0000-0002-0613-4419 UNSPECIFIED Roth, Matthias UNSPECIFIED UNSPECIFIED UNSPECIFIED Schmitz, Christoph UNSPECIFIED UNSPECIFIED UNSPECIFIED Schramm, Rene UNSPECIFIED UNSPECIFIED UNSPECIFIED Giot, Christophe UNSPECIFIED UNSPECIFIED UNSPECIFIED Wahlers, Thorsten C. W. UNSPECIFIED UNSPECIFIED UNSPECIFIED
URN:	urn:nbn:de:hbz:38-222924
DOI:	10.1093/ejcts/ezx103
Journal or Publication Title:	Eur. J. Cardio-Thorac. Surg.
Volume:	52
Number:	2
Page Range:	S. 281 - 288
Date:	2017
Publisher:	OXFORD UNIV PRESS INC
Place of Publication:	CARY
ISSN:	1873-734X
Language:	English
Faculty:	Unspecified
Divisions:	Unspecified
Subjects:	no entry
Uncontrolled Keywords:	Keywords Language HEMODYNAMIC PERFORMANCE; PROSPECTIVE MULTICENTER; PATIENT MISMATCH; REPLACEMENT; THROMBOSIS; ECHOCARDIOGRAPHY; BIOPROSTHESIS; GUIDELINES; MINISTERNOTOMY; REGURGITATION Multiple languages Cardiac & Cardiovascular Systems; Respiratory System; Surgery Multiple languages
Refereed:	Yes
URI:	http://kups.ub.uni-koeln.de/id/eprint/22292