Universität zu Köln

Gottschalk, Ingo, Gottschalk, Lea, Stressig, Ruediger, Ritgen, Jochen, Herberg, Ulrike, Breuer, Johannes, Oberhoffer, Renate, Willruth, Arne, Strizek, Brigitte ORCID: 0000-0003-3625-7097, Geipel, Annegret, Gembruch, Ulrich ORCID: 0000-0001-8284-4669 and Berg, Christoph (2017). Ebstein's Anomaly of the Tricuspid Valve in the Fetus A Multicenter Experience. Ultraschall Med., 38 (4). S. 427 - 437. STUTTGART: GEORG THIEME VERLAG KG. ISSN 1438-8782

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Abstract

Purpose To assess the spectrum of associated anomalies, the intrauterine course, the outcome and possible prognostic markers in prenatally diagnosed Ebstein's anomaly (EA). Materials and Methods All cases of EA diagnosed over a period of 13 years with a minimum follow-up of 1 year were retrospectively collected in 4 tertiary referral centers in Germany. Results In the study period 76 cases of EA were prenatally diagnosed. The mean gestational age at diagnosis was 25.0 weeks (range: 13 -35). 41 (53.9 %) cases were isolated and 35 (46.1 %) had other cardiac and/or extracardiac anomalies. 19 (25.0 %) pregnant women opted for termination of pregnancy, intrauterine fetal death occurred in 7 cases (9.2 %), neonatal death in 14 cases (18.4 %), death in infancy or childhood in 9 cases (11.8 %) and 27 children (35.5 %) were alive at the last follow-up. After exclusion of terminations, the only parameter inversely correlated with intrauterine survival was hydrops fetalis. Prognostic parameters significantly associated with postnatal non-survival were an abnormal Celermajer index (right atrium/heart ratio > 0.7), cardiomegaly (cardiothoracic circumference ratio > 0.5), absence of antegrade flow over the pulmonary valve and earlier diagnosis in pregnancy. Conclusion Prenatally diagnosed EA has a high morbidity and mortality with the highest loss rate in the intrauterine and neonatal period. In our study, hydrops fetalis was the only parameter significantly associated with intrauterine demise, while other prenatal markers were only significantly associated with postnatal mortality.

Item Type:	Journal Article
Creators:	Creators Email ORCID ORCID Put Code Gottschalk, Ingo UNSPECIFIED UNSPECIFIED UNSPECIFIED Gottschalk, Lea UNSPECIFIED UNSPECIFIED UNSPECIFIED Stressig, Ruediger UNSPECIFIED UNSPECIFIED UNSPECIFIED Ritgen, Jochen UNSPECIFIED UNSPECIFIED UNSPECIFIED Herberg, Ulrike UNSPECIFIED UNSPECIFIED UNSPECIFIED Breuer, Johannes UNSPECIFIED UNSPECIFIED UNSPECIFIED Oberhoffer, Renate UNSPECIFIED UNSPECIFIED UNSPECIFIED Willruth, Arne UNSPECIFIED UNSPECIFIED UNSPECIFIED Strizek, Brigitte UNSPECIFIED orcid.org/0000-0003-3625-7097 UNSPECIFIED Geipel, Annegret UNSPECIFIED UNSPECIFIED UNSPECIFIED Gembruch, Ulrich UNSPECIFIED orcid.org/0000-0001-8284-4669 UNSPECIFIED Berg, Christoph UNSPECIFIED UNSPECIFIED UNSPECIFIED
URN:	urn:nbn:de:hbz:38-223148
DOI:	10.1055/s-0042-107151
Journal or Publication Title:	Ultraschall Med.
Volume:	38
Number:	4
Page Range:	S. 427 - 437
Date:	2017
Publisher:	GEORG THIEME VERLAG KG
Place of Publication:	STUTTGART
ISSN:	1438-8782
Language:	English
Faculty:	Unspecified
Divisions:	Unspecified
Subjects:	no entry
Uncontrolled Keywords:	Keywords Language MALFORMATION; DYSPLASIA; DIAGNOSIS; PROGNOSIS; LESIONS Multiple languages Acoustics; Radiology, Nuclear Medicine & Medical Imaging Multiple languages
Refereed:	Yes
URI:	http://kups.ub.uni-koeln.de/id/eprint/22314