Universität zu Köln

Lukacisinova, Marta ORCID: 0000-0002-2519-8004 and Bollenbach, Tobias ORCID: 0000-0003-4398-476X (2017). Toward a quantitative understanding of antibiotic resistance evolution. Curr. Opin. Biotechnol., 46. S. 90 - 98. LONDON: CURRENT BIOLOGY LTD. ISSN 1879-0429

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Abstract

The rising prevalence of antibiotic resistant bacteria is an increasingly serious public health challenge. To address this problem, recent work ranging from clinical studies to theoretical modeling has provided valuable insights into the mechanisms of resistance, its emergence and spread, and ways to counteract it. A deeper understanding of the underlying dynamics of resistance evolution will require a combination of experimental and theoretical expertise from different disciplines and new technology for studying evolution in the laboratory. Here, we review recent advances in the quantitative understanding of the mechanisms and evolution of antibiotic resistance. We focus on key theoretical concepts and new technology that enables well-controlled experiments. We further highlight key challenges that can be met in the near future to ultimately develop effective strategies for combating resistance.

Item Type:	Journal Article
Creators:	Creators Email ORCID ORCID Put Code Lukacisinova, Marta UNSPECIFIED orcid.org/0000-0002-2519-8004 UNSPECIFIED Bollenbach, Tobias UNSPECIFIED orcid.org/0000-0003-4398-476X UNSPECIFIED
URN:	urn:nbn:de:hbz:38-223692
DOI:	10.1016/j.copbio.2017.02.013
Journal or Publication Title:	Curr. Opin. Biotechnol.
Volume:	46
Page Range:	S. 90 - 98
Date:	2017
Publisher:	CURRENT BIOLOGY LTD
Place of Publication:	LONDON
ISSN:	1879-0429
Language:	English
Faculty:	Faculty of Mathematics and Natural Sciences
Divisions:	Faculty of Mathematics and Natural Sciences > Department of Chemistry > Institute of Biochemistry
Subjects:	no entry
Uncontrolled Keywords:	Keywords Language GROWTH-RATE; ANTIMICROBIAL AGENTS; FITNESS LANDSCAPES; GENE-EXPRESSION; KEY INNOVATION; MECHANISMS; BACTERIA; SUSCEPTIBILITY; MUTATIONS; TOLERANCE Multiple languages Biochemical Research Methods; Biotechnology & Applied Microbiology Multiple languages
Refereed:	Yes
URI:	http://kups.ub.uni-koeln.de/id/eprint/22369