Universität zu Köln

Riera, Celine E., Tsaousidou, Eva ORCID: 0000-0003-2751-1911, Halloran, Jonathan, Follett, Patricia, Hahn, Oliver ORCID: 0000-0001-9015-4545, Pereira, Mafalda M. A., Ruud, Linda Engstroem, Alber, Jens, Tharp, Kevin, Anderson, Courtney M., Broenneke, Hella, Hampel, Brigitte, de Magalhaes Filho, Carlos Daniel, Stahl, Andreas, Bruening, Jens C. and Dillin, Andrew (2017). The Sense of Smell Impacts Metabolic Health and Obesity. Cell Metab., 26 (1). S. 198 - 217. CAMBRIDGE: CELL PRESS. ISSN 1932-7420

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Abstract

Olfactory inputs help coordinate food appreciation and selection, but their role in systemic physiology and energy balance is poorly understood. Here we demonstrate that mice upon conditional ablation of mature olfactory sensory neurons (OSNs) are resistant to diet-induced obesity accompanied by increased thermogenesis in brown and inguinal fat depots. Acute loss of smell perception after obesity onset not only abrogated further weight gain but also improved fat mass and insulin resistance. Reduced olfactory input stimulates sympathetic nerve activity, resulting in activation of beta-adrenergic receptors on white and brown adipocytes to promote lipolysis. Conversely, conditional ablation of the IGF1 receptor in OSNs enhances olfactory performance in mice and leads to increased adiposity and insulin resistance. These findings unravel a new bidirectional function for the olfactory system in controlling energy homeostasis in response to sensory and hormonal signals.

Item Type:	Journal Article
Creators:	Creators Email ORCID ORCID Put Code Riera, Celine E. UNSPECIFIED UNSPECIFIED UNSPECIFIED Tsaousidou, Eva UNSPECIFIED orcid.org/0000-0003-2751-1911 UNSPECIFIED Halloran, Jonathan UNSPECIFIED UNSPECIFIED UNSPECIFIED Follett, Patricia UNSPECIFIED UNSPECIFIED UNSPECIFIED Hahn, Oliver UNSPECIFIED orcid.org/0000-0001-9015-4545 UNSPECIFIED Pereira, Mafalda M. A. UNSPECIFIED UNSPECIFIED UNSPECIFIED Ruud, Linda Engstroem UNSPECIFIED UNSPECIFIED UNSPECIFIED Alber, Jens UNSPECIFIED UNSPECIFIED UNSPECIFIED Tharp, Kevin UNSPECIFIED UNSPECIFIED UNSPECIFIED Anderson, Courtney M. UNSPECIFIED UNSPECIFIED UNSPECIFIED Broenneke, Hella UNSPECIFIED UNSPECIFIED UNSPECIFIED Hampel, Brigitte UNSPECIFIED UNSPECIFIED UNSPECIFIED de Magalhaes Filho, Carlos Daniel UNSPECIFIED UNSPECIFIED UNSPECIFIED Stahl, Andreas UNSPECIFIED UNSPECIFIED UNSPECIFIED Bruening, Jens C. UNSPECIFIED UNSPECIFIED UNSPECIFIED Dillin, Andrew UNSPECIFIED UNSPECIFIED UNSPECIFIED
URN:	urn:nbn:de:hbz:38-225155
DOI:	10.1016/j.cmet.2017.06.015
Journal or Publication Title:	Cell Metab.
Volume:	26
Number:	1
Page Range:	S. 198 - 217
Date:	2017
Publisher:	CELL PRESS
Place of Publication:	CAMBRIDGE
ISSN:	1932-7420
Language:	English
Faculty:	Unspecified
Divisions:	Unspecified
Subjects:	no entry
Uncontrolled Keywords:	Keywords Language WHITE ADIPOSE-TISSUE; LEPTIN RECEPTOR; TARGETED DISRUPTION; ENERGY HOMEOSTASIS; EXPRESSING NEURONS; INSULIN-RECEPTORS; SKELETAL-MUSCLE; MICE LACKING; IGF-I; RAT Multiple languages Cell Biology; Endocrinology & Metabolism Multiple languages
Refereed:	Yes
URI:	http://kups.ub.uni-koeln.de/id/eprint/22515