Universität zu Köln

Rostami, Hadiseh Nowparast, Saville, Christopher W. N., Klein, Christoph, Ouyang, Guang ORCID: 0000-0001-8939-7443, Sommer, Werner ORCID: 0000-0001-5266-3445, Zhou, Changsong and Hildebrandt, Andrea (2017). COMT genotype is differentially associated with single trial variability of ERPs as a function of memory type. Biol. Psychol., 127. S. 209 - 220. AMSTERDAM: ELSEVIER. ISSN 1873-6246

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Abstract

Previous research on the association between intra-subject variability (ISV) in reaction times (RTs) and the Val(158)Met polymorphism of the catechol-o-methyltransferase gene (COMT; rs4680) has yielded mixed results. The present study compared the associations between COMT genotype and ISV in P3b latency measured during working and secondary memory tasks using residue iteration decomposition (RIDE) of single trial latencies. We compared the outcome of the present analyses with a previous analysis of the same data (N = 70, n-back tasks) using an alternative single-trial method. Additionally, we used RIDE to analyse the association between COMT genotype and ISV in an independent sample performing a different task (N = 91, face-recognition task). Analyses reconfirmed previous results from the n-back tasks, showing that Val alleles are associated with lower ISV. In the face recognition tasks, genotype interacted with task conditions, so Val homozygotes had higher ISV to unfamiliar faces than familiar ones but Met carriers showed no effect of familiarity. Moreover, in both datasets trial-by-trial RTs were predicted by P3b latencies. Therefore, the present data suggests that associations between COMT genotype and ISV depend on the type of cognitive processes, which may explain heterogeneity in previous results.

Item Type:	Journal Article
Creators:	Creators Email ORCID ORCID Put Code Rostami, Hadiseh Nowparast UNSPECIFIED UNSPECIFIED UNSPECIFIED Saville, Christopher W. N. UNSPECIFIED UNSPECIFIED UNSPECIFIED Klein, Christoph UNSPECIFIED UNSPECIFIED UNSPECIFIED Ouyang, Guang UNSPECIFIED orcid.org/0000-0001-8939-7443 UNSPECIFIED Sommer, Werner UNSPECIFIED orcid.org/0000-0001-5266-3445 UNSPECIFIED Zhou, Changsong UNSPECIFIED UNSPECIFIED UNSPECIFIED Hildebrandt, Andrea UNSPECIFIED UNSPECIFIED UNSPECIFIED
URN:	urn:nbn:de:hbz:38-225523
DOI:	10.1016/j.biopsycho.2017.06.002
Journal or Publication Title:	Biol. Psychol.
Volume:	127
Page Range:	S. 209 - 220
Date:	2017
Publisher:	ELSEVIER
Place of Publication:	AMSTERDAM
ISSN:	1873-6246
Language:	English
Faculty:	Unspecified
Divisions:	Unspecified
Subjects:	no entry
Uncontrolled Keywords:	Keywords Language REACTION-TIME VARIABILITY; INTRA-SUBJECT VARIABILITY; INTRAINDIVIDUAL VARIABILITY; VAL(158)MET POLYMORPHISM; LATENCY VARIABILITY; ATTENTION; PERSONALITY; FLUCTUATIONS; MECHANISMS; DISORDER Multiple languages Psychology, Biological; Behavioral Sciences; Psychology; Psychology, Experimental Multiple languages
Refereed:	Yes
URI:	http://kups.ub.uni-koeln.de/id/eprint/22552