Universität zu Köln

Paul, Christoph ORCID: 0000-0002-6458-0302, Heun, Christine, Mueller, Hans H., Fauser, Sascha, Kaymak, Hakan, Kazerounian, Sara, Sekundo, Walter, Mennel, Stefan, Meyer, Carsten H. ORCID: 0000-0002-0530-5298, Schmitz-Valckenberg, Steffen, Koss, Michael J., Feltgen, Nicolas and Bertelmann, Thomas (2017). IMPACT OF VITREORETINAL INTERFACE ARCHITECTURE ON SUCCESSFUL VITREOMACULAR TRACTION RESOLUTION IN EYES SCHEDULED FOR INTRAVITREAL OCRIPLASMIN THERAPY. Retin.-J. Retin. Vitr. Dis., 37 (7). S. 1252 - 1261. PHILADELPHIA: LIPPINCOTT WILLIAMS & WILKINS. ISSN 1539-2864

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Abstract

Purpose: To evaluate the impact of the vitreoretinal interface architecture, in specific the angle between the posterior vitreous cortex and the internal limiting membrane, on vitreomacular traction (VMT) resolution in eyes treated with intravitreally injected ocriplasmin (Jetrea). Methods: Retrospective, multicenter cohort study and exploratory data analysis. Spectral domain optical coherence tomography assessments were performed before scheduled ocriplasmin injections. General (age and sex) as well as ocular variables (lens status, presence of epiretinal membrane formations, horizontal diameter of VMT, central retinal thickness, and in particular various prespecified angles between the posterior vitreous cortex and internal limiting membrane) were analyzed to evaluate their impact on successful VMT resolution. Results: Fifty-nine eyes of 59 patients were included. Univariate analysis of age (odds ratio [OR]: 0.881; 95% CI: [0.812-0.955]; P = 0.0022) and lens status (OR: 11.03; 95% CI: [2.23-54.57]; P = 0.0033) had a significant impact on successful VMT resolution, whereas sex (OR: 0.668; 95% CI: [0.126-2.065]; P = 0.4906), epiretinal membrane formation (OR: 0.581; 95% CI: [0.168-2.006]; P = 0.3903), horizontal diameter of VMT (OR: 0.99930; 95% CI: [0.99825-1.00035]; P = 0.1886), and central retinal thickness (OR: 0.9985; 95% CI: [0.9934-1.00436]; P = 0.56) failed. The angle at 500 mm apart from the fovea centralis, irrespective if measured nasally (OR: 1.135; 95% CI: [1.013-1.272]; P = 0.0289) or temporally (OR: 1.099; 95% CI: [1.001-1.208]; P = 0.0485), showed a significant correlation with VMT resolution. Conclusion: The angle between the posterior vitreous cortex and the internal limiting membrane 500 mm apart from the fovea centralis correlates with VMT resolution and may be a clinically useful marker for selection of patients to be treated with ocriplasmin. This observation needs to be proven in a prospective confirmatory investigation.

Item Type:	Journal Article
Creators:	Creators Email ORCID ORCID Put Code Paul, Christoph UNSPECIFIED orcid.org/0000-0002-6458-0302 UNSPECIFIED Heun, Christine UNSPECIFIED UNSPECIFIED UNSPECIFIED Mueller, Hans H. UNSPECIFIED UNSPECIFIED UNSPECIFIED Fauser, Sascha UNSPECIFIED UNSPECIFIED UNSPECIFIED Kaymak, Hakan UNSPECIFIED UNSPECIFIED UNSPECIFIED Kazerounian, Sara UNSPECIFIED UNSPECIFIED UNSPECIFIED Sekundo, Walter UNSPECIFIED UNSPECIFIED UNSPECIFIED Mennel, Stefan UNSPECIFIED UNSPECIFIED UNSPECIFIED Meyer, Carsten H. UNSPECIFIED orcid.org/0000-0002-0530-5298 UNSPECIFIED Schmitz-Valckenberg, Steffen UNSPECIFIED UNSPECIFIED UNSPECIFIED Koss, Michael J. UNSPECIFIED UNSPECIFIED UNSPECIFIED Feltgen, Nicolas UNSPECIFIED UNSPECIFIED UNSPECIFIED Bertelmann, Thomas UNSPECIFIED UNSPECIFIED UNSPECIFIED
URN:	urn:nbn:de:hbz:38-226161
DOI:	10.1097/IAE.0000000000001371
Journal or Publication Title:	Retin.-J. Retin. Vitr. Dis.
Volume:	37
Number:	7
Page Range:	S. 1252 - 1261
Date:	2017
Publisher:	LIPPINCOTT WILLIAMS & WILKINS
Place of Publication:	PHILADELPHIA
ISSN:	1539-2864
Language:	English
Faculty:	Unspecified
Divisions:	Unspecified
Subjects:	no entry
Uncontrolled Keywords:	Keywords Language OPTICAL COHERENCE TOMOGRAPHY; MACULAR HOLES; MIVI-TRUST; ADHESION; OUTCOMES; EXPERIENCE; EFFICACY Multiple languages Ophthalmology Multiple languages
Refereed:	Yes
URI:	http://kups.ub.uni-koeln.de/id/eprint/22616